Meibomian gland dysfunction patients benefit in ocular parameters and tear chemokines after thermal pulsation treatment.
Meibomian gland dysfunction patients benefit in ocular parameters and tear chemokines after thermal pulsation treatment.
复制标题
DOI：
10.7150/ijms.76603
复制
发表时间：
2023
影响因子：
3.6
通讯作者：
Gong L
中科院分区：
文献类型：
--
作者：
Liu W;Lin T;Gong L
目的：探讨热脉冲治疗对睑板腺功能、眼部参数及泪液炎性细胞因子的影响。研究方法：25名MGD参与者接受了12分钟的热脉冲治疗，而25名MGD参与者接受了手动热敷治疗。检查MGD相关参数，包括睑板腺功能（MGE、MQ和眼睑边缘）、泪液稳定性（NIKBUT、FBUT和LLT）、泪液分泌量（SIT和TMH），并获得OSDI问卷。检测泪液中趋化因子β 1、IFN-γ、IL-8、IP-10和MCP-1，并分析其与MGD相关参数和OSDI的相关性。结果如下：与温敷受试者相比，在3个月时，发现热脉动治疗的OSDI、眼睑边缘和撕裂稳定性改善更多（OSDI：*p = 0.014，眼睑边缘：*p = 0.021，LLT：**p = 0.008，CFS：*p = 0.028）。热脉冲组的IP-10和P2P水平比温敷组降低更多（IP-10：*p = 0.021，P2P：*p = 0.039）。IP-10与MQ正相关（r = 0.522，*p = 0.037），与泪液稳定性负相关（r =-0.613，**p = 0.002），OSDI仅与IL-8正相关（r = 0.679，*p < 0.001）。角膜厚度的降低与角膜上皮损伤（r = 0.557，**p = 0.006）和角膜厚度降低（r = 0.49，*p = 0.019）呈正相关。结论：热脉冲治疗可能通过抑制MGD患者眼表中的泪液CXCL趋化因子而明显改善MGD，临床上证明了其有效性和耐受性。
Objectives: To investigate the effect of thermal pulsation treatment on meibomian gland function, ocular parameters and tear inflammatory cytokines compared with the warm compress group. Methods: Twenty-five participants with MGD underwent a 12-minute thermal pulsation treatment, while 25 participants with MGD underwent manual warm compress treatment. MGD related parameters, including meibomian gland function (MGE, MQ and lid margin), tear stability (NIKBUT, FBUT and LLT), tear secretion (SIT, and TMH), were examined and OSDI questionnaire was also obtained. Tear chemokines (MIG, IFN-γ, IL-8, IP-10 and MCP-1) were examined and analyzed the correlations with MGD related parameters and OSDI. Results: Compared with warm compress subjects, OSDI, lid margin and tear stability were found improved more in thermal pulsation treatment at 3 months (OSDI: *p = 0.014, lid margin: *p = 0.021, LLT: **p = 0.008, CFS: *p = 0.028). The level of IP-10 and MIG decreased more in thermal pulsation group than in warm compress group (IP-10: *p = 0.021, MIG: *p = 0.039). IP-10 was positively correlated with MQ (r = 0.522, *p = 0.037) and negatively correlated with tear stability (r = -0.613, **p = 0.002), and OSDI was only positively correlated with IL-8 (r = 0.679, ***p < 0.001). The decrease of MIG was positively correlated with less corneal epithelium injury (r = 0.557, **p = 0.006) and meibograde (r = 0.49, *p = 0.019). Conclusions: Thermal pulsation treatment obviously improved MGD probably by attenuating tear CXCL chemokines in ocular surface of MGD patients, which demonstrated an efficacy and well-tolerated therapy in clinical.
登录
查看更多内容
单一的矢量热脉动处理用于Meibomian腺功能障碍会增加舒适的隐形眼镜每天大约4个小时。
DOI：
10.2147/opth.s153297
发表时间：
2018
期刊：
Clinical ophthalmology (Auckland, N.Z.)
影响因子：
--
作者：
Blackie CA;Coleman CA;Nichols KK;Jones L;Chen PQ;Melton R;Kading DL;O'Dell LE;Srinivasan S
通讯作者：
Srinivasan S
影响因子：
5.9
作者：
Park, Bongkyun;Jo, Kyuhyung;Kim, Chan-Sik
通讯作者：
Kim, Chan-Sik
影响因子：
1.4
作者：
Gao, Yu-Fei;Liu, Rong-Jun;Qi, Hong
通讯作者：
Qi, Hong
DOI：
10.2147/opth.s109663
发表时间：
2016
期刊：
Clinical ophthalmology (Auckland, N.Z.)
影响因子：
--
作者：
Blackie CA;Coleman CA;Holland EJ
通讯作者：
Holland EJ
影响因子：
6.4
作者：
Craig, Jennifer P.;Nelson, J. Daniel;Sullivan, David A.
通讯作者：
Sullivan, David A.