Antibiotic chemotherapy of onchocerciasis:: In a bovine model, killing of adult parasites requires a sustained depletion of endosymbiotic bacteria (Wolbachia species)
Antibiotic chemotherapy of onchocerciasis:: In a bovine model, killing of adult parasites requires a sustained depletion of endosymbiotic bacteria (Wolbachia species)
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DOI：
10.1086/462426
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发表时间：
2005-10-15
影响因子：
6.4
通讯作者：
Trees, AJ
中科院分区：
文献类型：
--
作者：
Gilbert, J;Nfon, CK;Trees, AJ
开发对旋绕盘尾丝虫成虫（即，杀大型丝虫剂）是控制人类盘尾丝虫病的研究优先事项。使用牛O.ochengi感染，我们研究了土霉素在短期强化方案（SIR; 10 mg/kg每日，持续14天）中给药与长期间歇方案（PIR; 20 mg/kg每月，持续6个月）或两者结合（COM）对蠕虫及其内共生细菌（Wolbachia属）活力的影响。长期处理消除了> 80%（COM）或> 60%（PIR）的成年雌性蠕虫（P <0.001）的沃尔巴克氏体生物。相反，SIR不杀巨丝虫，仅短暂耗尽沃尔巴克氏体密度，其在治疗后24周重新填充蠕虫组织。这些结果明确表明四环素类药物对盘尾丝虫感染具有杀灭巨丝虫的潜力，并表明间歇性、长期给药比连续短期治疗更有效。
Development of a drug lethal to adult Onchocerca volvulus (i.e., macrofilaricide) is a research priority for the control of human onchocerciasis. Using bovine O.ochengi infections, we investigated the effects of oxytetracycline administered in a short intensive regimen (SIR; 10 mg/kg daily for 14 days), compared with a prolonged intermittent regimen (PIR; 20 mg/kg monthly for 6 months) or a combination of both (COM), on the viability of adult worms and their endosymbiotic bacteria (Wolbachia species). The long-term treatments eliminated > 80% ( COM) or > 60% (PIR) of adult female worms (P 001 of Wolbachia organisms. Conversely, SIR was not macrofilaricidal and only transiently depleted Wolbachia densities, which repopulated worm tissues by 24 weeks after treatment. These results unequivocally demonstrate the macrofilaricidal potential of tetracyclines against Onchocerca infection and suggest that intermittent, protracted administration will be more effective than continuous shorter term treatment.