COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses
COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses
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DOI：
10.1016/j.jare.2020.03.005
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发表时间：
2020-07-01
影响因子：
10.7
通讯作者：
Siddique, Rabeea
中科院分区：
文献类型：
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作者：
Shereen, Muhammad Adnan;Khan, Suliman;Siddique, Rabeea
冠状病毒病19（COVID-19）是由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的高度传播性和致病性病毒感染，出现在中国武汉并在全球蔓延。基因组分析显示，SARS-CoV-2与严重急性呼吸道综合征样（SARS样）蝙蝠病毒在遗传学上相关，因此蝙蝠可能是主要的宿主。起源和转移到人类的中间来源尚不清楚，但人与人之间的快速转移已得到广泛证实。目前尚无临床批准的抗病毒药物或疫苗可用于对抗COVID-19。然而，在临床试验中，很少有广谱抗病毒药物被评估用于对抗COVID-19，导致临床恢复。本文对COVID-19感染的发生和致病性与之前的人冠状病毒严重急性呼吸综合征冠状病毒（SARS-CoV）和中东呼吸综合征冠状病毒（MERS-CoV）进行了总结和比较分析。我们还讨论了开发有效疫苗和治疗组合以科普这种病毒爆发的方法。(C)2020年，任作家。由Elsevier B. V.代表开罗大学出版。这是一个在CC BY-NC-ND许可证下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/4.0/）。
The coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in Wuhan, China and spread around the world. Genomic analysis revealed that SARS-CoV-2 is phylogenetically related to severe acute respiratory syndrome-like (SARS-like) bat viruses, therefore bats could be the possible primary reservoir. The intermediate source of origin and transfer to humans is not known, however, the rapid human to human transfer has been confirmed widely. There is no clinically approved antiviral drug or vaccine available to be used against COVID-19. However, few broad-spectrum antiviral drugs have been evaluated against COVID-19 in clinical trials, resulted in clinical recovery. In the current review, we summarize and comparatively analyze the emergence and pathogenicity of COVID-19 infection and previous human coronaviruses severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV). We also discuss the approaches for developing effective vaccines and therapeutic combinations to cope with this viral outbreak. (C) 2020 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).