Intracellular PO2 of the carotid body.
Intracellular PO2 of the carotid body.
复制标题
颈动脉体细胞内 PO2。
DOI：
10.1007/0-306-46825-5_62
复制
发表时间：
2000
影响因子：
--
通讯作者：
Lahiri,S
中科院分区：
文献类型：
--
作者：
Wilson,DF;Evans,SM;Rozanov,C;Roy,A;Koch,CJ;Laughlin,KM;Lahiri,S
颈动脉体起源于胚胎发育过程中的神经嵴，是人体最著名的氧感觉组织之一。它已被广泛研究，部分是因为它在调节呼吸速率方面具有明确的功能，部分是因为传入神经可以容易地分离并测量化学感受活性。在颈动脉体中，主要的传感器已被证明是线粒体氧化磷酸化，通过氧与细胞色素c氧化酶的反应（Wilson等，1994; Wilson等，本论文集）。这就提出了关于氧气感测发生时的氧气压力的机制的问题。线粒体的细胞色素c氧化酶反应的氧依赖性一直是有争议的主题，有报道称其仅在约1 mm Hg以下依赖于氧浓度（Chance，1988），或在30 mm Hg及以下依赖于氧（Wilson等，1979）。因此，为了了解颈动脉体的氧气传感，了解颈动脉体细胞中的氧气压力非常重要。
The carotid body originates from the neural crest during embryonic development and one of the best known oxygen sensory tissues of the body. It has been extensively studied, in part because it has a well defined function in regulating the respiratory rate and in part because the afferent nerve can be readily isolated and the chemosensory activity measured. In the carotid body, the primary sensor has been shown to be mitochondrial oxidative phosphorylation, through the reaction of oxygen with cytochrome c oxidase (Wilson et al. 1994; Wilson et al, this proceedings). This has raised questions concerning the mechanism (s) of the oxygen pressures at which oxygen sensing occurs. The oxygen dependence of the cytochrome c oxidase reaction of mitochondria has been the subject of controversy, with reports that it is oxygen concentration dependent only below about 1 mm Hg (Chance, 1988) or that it is oxygen dependent at 30 mm Hg and below (Wilson et al. 1979). Thus, in order to understand oxygen sensing by the carotid body it is important to know the oxygen pressure in the cells of the carotid body.