Genetic polymorphisms of glutathione S-transferase T1 (GSTT1) and susceptibility to gastric cancer:: a meta-analysis
Genetic polymorphisms of glutathione S-transferase T1 (GSTT1) and susceptibility to gastric cancer:: a meta-analysis
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DOI：
10.1111/j.1349-7006.2006.00207.x
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发表时间：
2006-06-01
期刊：
影响因子：
5.7
通讯作者：
Saadat, M
中科院分区：
文献类型：
--
作者：
Saadat, M
谷胱甘肽S-转移酶T1（GSTT 1）多态性与胃癌风险之间的关联已在许多已发表的研究中得到证实和反驳。这些研究大多基于小样本量。我们对2005年8月发表的研究进行了荟萃分析，以获得与GSTT 1多态性相关的胃癌风险的更精确估计。在本研究中，16项病例对照研究（共6717例受试者）符合荟萃分析的条件。研究之间没有异质性的证据。GSTT 1缺失基因型使胃癌风险增加1.06倍，但无显著性差异（95%可信区间[CI]：0.94-1.19）。然而，在种族群体的分析中，我们观察到与GSTT 1状态相关的明显差异。限制种族分析，GSTT 1基因型的合并比值比在白人中为1.27（95%CI：1.03-1.57），在亚洲人中为0.98（95%CI：0.86-1.13）。谷胱甘肽S-转移酶M1（GSTM 1）和GSTT 1参与多种化合物的解毒，有些在酶之间重叠，有些是高度特异性的。为了研究谷胱甘肽S-转移酶基因型是否与胃癌风险相关，还进行了GSTT 1和GSTM 1基因型联合分析。有一个显着的趋势，风险与零，一个和两个推定的高风险基因型（卡方系数（2）= 9.326，d. f. = 1，P = 0.0023）。GSTM 1和GSTT 1缺失基因型与GSTM 1和GSTT 1均为活性基因型者相比，胃癌发生的危险性增加（OR = 2.08，95% CI：1.42-3.10）。
The association between glutathione S-transferase T1 (GSTT1) polymorphism and gastric cancer risk has been both confirmed and refuted in a number of published studies. Most of these studies were based on small sample sizes. We carried out a meta-analysis of the research published up to August 2005 to obtain more precise estimates of gastric cancer risk associated with GSTT1 polymorphism. In the present study, 16 case-control studies (with a total of 6717 subjects) were eligible for meta-analysis. There was no evidence of heterogeneity between the studies. The GSTT1 null genotype conferred a 1.06-fold increased risk of gastric cancer, which was not significant (95% confidence interval [CI]: 0.94-1.19). However, in the analysis of ethnic groups, we observed distinct differences associated with GSTT1 status. Restricting analyses to ethnic groups, the pooled odd ratios for the GSTT1 genotype were 1.27 in Caucasians (95% CI: 1.03-1.57) and 0.98 in Asians (95% CI: 0.86-1.13). Glutathione S-transferase M1 (GSTM1) and GSTT1 are involved in detoxification of a variety of compounds, some that overlap between enzymes and some that are highly specific. To investigate whether the profile of glutathione S-transferase genotypes was associated with risk of gastric cancer, further analyses combining the GSTT1 and GSTM1 genotypes were also carried out. There was a significant trend in risk associated with zero, one and two putative high-risk genotypes (chi(2) = 9.326, d.f. = 1, P = 0.0023). Those who had null genotypes of GSTM1 and GSTT1 had an increased gastric cancer risk compared with those who had both active genes (odds ratio = 2.08, 95% CI: 1.42-3.10).