The genome sequence of the SARS-associated coronavirus
The genome sequence of the SARS-associated coronavirus
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DOI：
10.1126/science.1085953
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发表时间：
2003-05-30
期刊：
影响因子：
56.9
通讯作者：
Roper, RL
中科院分区：
文献类型：
--
作者：
Marra, MA;Jones, SJM;Roper, RL
我们对严重急性呼吸综合征（SARS）相关冠状病毒Tor 2分离株的29,751个碱基的基因组进行了测序。基因组序列显示，这种冠状病毒与其他已知的冠状病毒只有中度相关，包括两种人类冠状病毒HCoV-OC 43和HCoV-229 E。对预测的病毒蛋白的系统发育分析表明，该病毒与先前已知的三组冠状病毒中的任何一组都不太相似。基因组序列将有助于诊断SARS病毒感染人类和潜在的动物宿主（使用聚合酶链反应和免疫学测试），开发抗病毒药物（包括中和抗体），并确定疫苗开发的假定表位。
We sequenced the 29,751-base genome of the severe acute respiratory syndrome (SARS)-associated coronavirus known as the Tor2 isolate. The genome sequence reveals that this coronavirus is only moderately related to other known coronaviruses, including two human coronaviruses, HCoV-OC43 and HCoV-229E. Phylogenetic analysis of the predicted viral proteins indicates that the virus does not closely resemble any of the three previously known groups of coronaviruses. The genome sequence will aid in the diagnosis of SARS virus infection in humans and potential animal hosts (using polymerase chain reaction and immunological tests), in the development of antivirals (including neutralizing antibodies), and in the identification of putative epitopes for vaccine development.