Incidence of schizophrenia and other psychoses in ethnic minority groups: results from the MRC AESOP study
Incidence of schizophrenia and other psychoses in ethnic minority groups: results from the MRC AESOP study
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DOI：
10.1017/s0033291706008774
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发表时间：
2006-11-01
影响因子：
6.9
通讯作者：
Murray, Robin M.
中科院分区：
文献类型：
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作者：
Fearon, Paul;Kirkbride, James B.;Murray, Robin M.
背景据报告，英格兰非洲-加勒比人口中精神分裂症的发病率有所上升。我们试图澄清（a）其他精神障碍的发病率是否增加，（B）精神病是否在其他少数民族群体中增加，以及（c）特定年龄或性别群体是否特别危险。我们确定了所有的人（n = 568），年龄16-64岁的二级服务，他们的第一个精神病症状在三个明确的英语地区（超过2年的时间在东南伦敦和诺丁汉和9个月的时间在布里斯托）。计算所有主要种族的所有主要精神病综合征的标准化发病率和发病率比（IRR）。我们发现，无论是非洲裔卡比恩人（精神分裂症9.1，躁狂精神病8.0）和非洲黑人（精神分裂症5.8，躁狂精神病6.2）的男性和女性的精神分裂症和躁狂精神病的IRR都非常高。其他少数民族群体的IRR略有增加，所有少数民族群体的抑郁性精神病和其他精神病的发病率也略有增加。在我们的研究中，这些上升的比率在所有年龄组中都很明显。少数民族群体患所有精神病的风险增加，但非洲加勒比人和非洲黑人患精神分裂症和躁狂症的风险尤其高。这些研究结果表明，（a）在非洲-加勒比人和非洲黑人中存在其他风险因素，或者这些因素在这些群体中特别普遍，（h）这些因素增加了这些群体中精神分裂症和躁狂症的风险。
Background. The incidence of schizophrenia in the African-Caribbean population in England is reported to be raised. We sought to clarify whether (a) the rates of other psychotic disorders are increased, (b) whether psychosis is increased in other ethnic minority groups, and (c) whether particular age or gender groups are especially at risk.Method. We identified all people (n = 568) aged 16-64 years presenting to secondary services with their first psychotic symptoms in three well-defined English areas (over a 2-year period in Southeast London and Nottingham and a 9-month period in Bristol). Standardized incidence rates and incidence rate ratios (IRR) for all major psychosis syndromes for all main ethnic groups were calculated.Results. We found remarkably high IRRs for both schizophrenia and manic psychosis in both African-Carlbbeans (schizophrenia 9.1, manic psychosis 8.0) and Black Africans (schizophrenia 5.8, manic psychosis 6.2) in men and women. IRRs in other ethnic minority groups were modestly increased as were rates for depressive psychosis and other psychoses in all minority groups. These raised rates were evident in all age groups in our study.Conclusions. Ethnic minority groups are at increased risk for all psychotic illnesses but African-Caribbeans and Black Africans appear to be at especially high risk for both schizophrenia and mania. These findings suggest that (a) either additional risk factors are operating in African-Caribbeans and Black Africans or that these factors are particularly prevalent in these groups, and that (h) such factors increase risk for schizophrenia and mania in these groups.