Fluctuations in Antibody Titers against Enterovirus D68 in Pediatric Sera Collected in a Community before, during, and after a Possible Outbreak
Fluctuations in Antibody Titers against Enterovirus D68 in Pediatric Sera Collected in a Community before, during, and after a Possible Outbreak
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DOI：
10.7883/yoken.jjid.2019.056
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发表时间：
2020-01-01
影响因子：
2.2
通讯作者：
Oshitani, Hitoshi
中科院分区：
文献类型：
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作者：
Kadji, Francois Marie Ngako;Nishimura, Hidekazu;Oshitani, Hitoshi
我们之前报道了2015年秋季儿童肠道病毒（EV）-D 68感染的医院流行病学研究，间接推断日本仙台爆发疫情。在本研究中，使用中和抗体滴度测定法分析了仙台社区儿童（0-6岁;无传染病症状）在4个时期（可能爆发期前1年，前6个月，后立即和后1年）收集的血清，以确定社区儿童对EV-D 68感染的免疫水平。经证实，在可能的疫情爆发期间，免疫水平有所上升，但在一年内逐渐下降，没有再次爆发。这些结果提供了背景信息，支持我们以前的医院为基础的监测研究的结果。
We previously reported a hospital-based epidemiological study on enterovirus (EV)-D68 infection among children during the autumn of 2015, which indirectly inferred an outbreak in Sendai, Japan. In this study, stocked sera of children (aged 0-6 years; without symptoms of infectious diseases) in the Sendai community collected during 4 periods (1 year before, 6 months before, immediately after, and 1 year after the possible outbreak period) were analyzed using the neutralization antibody titer assay to determine community children's immunity levels against EV-D68 infection. The immunity levels were confirmed to have increased during the possible outbreak period and to have gradually waned over 1 year without another outbreak. These results provide background information supporting the results of our previous hospital-based surveillance study.