AGE-DEPENDENCY AND REGIONAL DISTRIBUTION OF ENKEPHALINERGIC NERVES IN HUMAN-PROSTATE
AGE-DEPENDENCY AND REGIONAL DISTRIBUTION OF ENKEPHALINERGIC NERVES IN HUMAN-PROSTATE
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DOI：
10.1159/000281539
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发表时间：
1989-11-01
影响因子：
1.6
通讯作者：
MELCHIOR, H
中科院分区：
文献类型：
--
作者：
JUNGBLUT, T;AUMULLER, G;MELCHIOR, H
使用高度特异性的多克隆抗体对青少年和成人前列腺中肽能神经的区域分布进行了免疫组化研究。在与幼腺平滑肌密切相关的背外侧间质中检测到显示Met-脑啡肽、Leu-脑啡肽、heptaptide和octapeptide免疫反应的神经。间质血管和尿道周围的免疫反应性较弱。上皮下腺泡周围神经显示亮氨酸脑啡肽。甲硫氨酸脑啡肽，八肽和heptapetide免疫反应性被发现在少数情况下。最突出的免疫反应与八肽抗血清，其次是由甲硫氨酸脑啡肽，亮氨酸脑啡肽和七肽降序。其密度随年龄增长而降低。抗β-内啡肽，α-新内啡肽，β-新内啡肽和强啡肽A与前列腺神经呈阳性反应。所描述的区域分布模式有利于突触后肽能交感神经支配的前列腺基质与经典的神经递质。
The regional distribution of peptidergic nerves in the juvenile and adult human prostate has been studied immunohistochemically using highly specific polyclonal antibodies. Nerves displaying immunoreactivity of Met-enkephalin, Leu-enkephalin, heptapetide and octapeptide were detected in the dorsolateral stroma closely related to smooth muscle predominantly of juvenile glands. A less strong immunoreactivity was present around stromal vessels and periurethral. Subepithelial periacinar nerves showing Leu-enkephalin. Met-enkephalin, octa- and heptapetide immunoreactivity were found in a few instances. The most prominent immunoreaction was achieved with octapeptide antiserum, followed in decreasing order by Met-enkephalin, Leu-enkephalin and heptapeptide. Their density decreased with age. Antisera against .beta.-endorphin, .alpha.-neoendorphin, .beta.-neoendorphin and dynorphin A gave to positive immunoreaction with prostatic nerves. The regional distribution pattern described is in favor of a postsynaptic peptidergic sympathetic innervation of prostatic stroma acting with classical neurotransmitters.