A ventricular assist device powered by conditioned skeletal muscle.
A ventricular assist device powered by conditioned skeletal muscle.
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由调节骨骼肌提供动力的心室辅助装置。
DOI：
10.1016/s0003-4975(99)00615-3
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Olsen,DB
中科院分区：
文献类型：
--
作者：
Whalen,RL;Richards,CL;Lim,GW;Sherman,CW;Norman,JC;Bearnson,GB;Burns,GL;Olsen,DB
我们正在开发和测试一种新的心室辅助装置（VAD），该装置由状态骨骼肌提供动力。方法为了评估VAD硬件和制定肌肉训练方案，8头小牛在研究中使用了右背阔肌。实验进行了大约4个月的时间。结果II型肌纤维（快肌纤维）向I型肌纤维（慢肌纤维）转化显著。然而，这与设备性能没有很好的相关性。该装置的脑卒中容量范围约为17至90cc。尽管使用了相同的硬件、手术程序和训练方案，但结果却存在差异。结论：前8项研究的结果使我们推测，即使肌肉在远低于全身血压水平的压力下工作，灌注也可能很重要。为了增加组织灌注，我们计划研究热诱导血管生成作为增加组织血流量的可能机制。
BackgroundWe are developing and testing a new ventricular assist device (VAD) to be powered by conditioned skeletal muscle.MethodsTo evaluate the VAD hardware and to develop a muscle training regimen, 8 calves have been used in studies in which the right latissimus dorsi muscle was employed. The experiments were carried out to an approximately 4-month duration.ResultsThere was significant conversion of type II (fast twitch) to type I (slow twitch) muscle fibers. This did not correlate well, however, with device performance. The device stroke volumes ranged from approximately 17 to 90 cc. This variability of outcome occurred despite the fact that identical hardware, surgical procedures, and training regimens were employed.ConclusionsThe results from the first eight studies lead us to speculate that perfusion may be important even when the muscle is working at pressures much lower than systemic blood pressure levels. In an attempt to augment tissue perfusion, we plan to investigate thermally induced angiogenesis as a possible mechanism for increasing blood flow to the tissue.