[Morbidity in Chagas' disease. IV. Longitudinal study of 10 years in Pains and Iguatama, Minas Gerais, Brazil].
[Morbidity in Chagas' disease. IV. Longitudinal study of 10 years in Pains and Iguatama, Minas Gerais, Brazil].
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DOI：
10.1590/s0074-02761985000100011
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发表时间：
1985-01-01
影响因子：
2.8
通讯作者：
Willcox, H P
中科院分区：
文献类型：
--
作者：
Coura, J R;de Abreu, L L;Willcox, H P
在巴西米纳斯吉拉斯州的南美锥虫病流行区进行了一项“病例-对照”型的演变研究，采用两次间隔10年（1974-1984）的横断面评价。患者按性别和年龄配对。在第一个横断面研究中，264对一个血清学阳性，另一个血清学阴性的T。包括Cruzi抗体。在10年后的第二次评估中，在先前血清学阳性的患者和216名血清学阴性的患者中找到了235名患者，但只有110对患者可以重新组合和重新检查（临床检查、心电图和心脏和食管的Rx）。血清学阳性而无症状者10年内心脏病发病率为38.3%。另一方面，有恶化的24%的患者与chagglutinocardiopathy自第一次检查。考虑到疾病的所有临床形式，34.5%的患者的临床情况恶化，57.3%的患者无变化，8.2%的患者情况改善。总病死率分别为23%和10.6%，心脏病病死率分别为17%和23.3%。男性的死亡率是女性的两倍，主要集中在30至59岁的年龄组。
An evolutive study of the "case-control" type was carried out in an endemic area of Chagas' disease in Minas Gerais State, Brazil, using two cross-section evaluations with an interval of ten years between them (1974-1984). Patients were paired for sex and age. In the first cross-section study 264 pairs one with a positive serology and the other with a negative serology for T. cruzi antibodies were included. In the second evaluation, ten years later, 235 patients among those with previous positive serology and 216 with negative serology were located, but only 110 pairs could be recomposed and reexamined (clinical examination, ECG and Rx of the heart and esophagus). The incidence of chagasic cardiopathy in the cases with positive serology but previously assymptomatic was 38.3% during the ten year period. On the other hand there was a deterioration in 24% of the patients with chagasic cardiopathy since the first examination. Considering all clinical forms of the disease in 34.5% of the patients the clinical situation deteriorated, in 57.3% there was no change and in 8.2% the situation improved. The general mortality in the period was 23% in the chagasic group and 10.6% in the control group, but the lethality by cardiopathy was 17% in chagasic group and only 23.3% in the control group. The mortality was twice as high in males than in females, mainly in the age group from 30 to 59 years.