Trends in Antipseudomonal Agent Use Based on the 2006 to 2015 Sales Data in Japan
Trends in Antipseudomonal Agent Use Based on the 2006 to 2015 Sales Data in Japan
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DOI：
10.1248/bpb.b21-00004
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发表时间：
2021-06-01
影响因子：
2
通讯作者：
Muraki, Yuichi
中科院分区：
文献类型：
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作者：
Ebisui, Ai;Inose, Ryo;Muraki, Yuichi
铜绿假单胞菌耐药性是世界范围内的主要问题。耐药性与抗生素使用不当有关。由于抗假单胞菌药物具有广谱性，因此必须适当使用。本研究的目的是根据2006年至2015年的销售数据阐明日本抗假单胞菌药物的使用趋势。抗假单胞菌药物的总使用量显着增加（r = 0.10，P-（趋势）= 0.00040）。全年氟喹诺酮类药物使用比例最高，占88.6- 91.4%。哌拉西林/他唑巴坦的使用显著增加。这些药物的使用增加可能是由于推出了更高的剂量和额外的适应症。另一方面，对于抗假单胞菌药物，肠外碳青霉烯类的使用率为2.7- 3.7%，但多年来一直保持不变。在日本，已经引入了许可和通知系统，以防止在医疗机构中不适当地使用非肠道碳青霉烯类。据推测，这些努力抑制了肠外碳青霉烯类的不当使用。本研究阐明了2006年至2015年日本抗假单胞菌药物的使用趋势。重要的是要继续监测抗假单胞菌药物的使用，以进行适当的抗菌药物耐药性措施。
Pseudomonas aeruginosa resistance is a major issue worldwide. Drug resistance is related to inappropriate antibiotic use. Because antipseudomonal agents have a wide spectrum, they must be used appropriately. The purpose of this study was to clarify the trends in antipseudomonal agent use in Japan based on sales data from 2006 to 2015. The total antipseudomonal agent use was increased significantly (r = 0.10, P-for (trend) = 0.00040). The proportion of fluoroquinolones use was the highest throughout the year, accounting for 88.6-91.4%. The use of piperacillin/tazobactam significantly increased. The increased use of these drugs may be due to the launch of higher doses and additional indications. On the other hand, for antipseudomonal agents, parenteral carbapenems use was 2.7-3.7%, but it has remained unchanged over the years. In Japan, permit and notification systems have been introduced to prevent the inappropriate use of parenteral carbapenems in medical institutions. It was speculated that these efforts suppressed the inappropriate use of parenteral carbapenems. This study clarified the trend of antipseudomonal agent use in Japan from 2006 to 2015. It is important to continue monitoring antipseudomonal agents use to conduct appropriate antimicrobial resistance measures.