BIOCHEMICAL-CHANGES IN THE COLLAGENOUS MATRIX OF OSTEOPOROTIC AVIAN BONE
BIOCHEMICAL-CHANGES IN THE COLLAGENOUS MATRIX OF OSTEOPOROTIC AVIAN BONE
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DOI：
10.1042/bj3101045
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发表时间：
1995-09-15
影响因子：
4.1
通讯作者：
BAILEY, AJ
中科院分区：
文献类型：
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作者：
KNOTT, L;WHITEHEAD, CC;BAILEY, AJ
关于禽骨胶原基质的成分变化与骨质疏松时骨脆性增加的关系，尚未进行详细的生化分析。我们已经证明，禽骨中的骨质疏松症当然不仅仅是磷灰石和胶原的简单丢失，而是涉及胶原分子的生物化学以及随后的纤维物理性质的重大变化。机械强度的降低和热稳定性的变化可能直接与翻译后修饰的变化有关，即赖氨酸羟化和分子间交联键的变化。羟化的增加和交联度的变化与胶原的周转增加是一致的，可能是试图启动修复机制，事实上，这会导致骨骼脆性的增加。显然，在禽类骨质疏松症中，新合成的胶原蛋白存在翻译后修饰，这些变化可能在疾病的发病机制中发挥作用。
No detailed biochemical analysis has been carried out of the compositional changes in the collagen matrix of avian bone in relation to increased bone fragility in osteoporosis. We have shown that osteoporosis in avian bone is certainly not just a simple loss of apatite and collagen, but involves significant changes in the biochemistry of the collagen molecule and consequently in the physical properties of the fibre. The decreased mechanical strength and the change in the thermal stability can be directly related to changes in post-translational modifications, i.e. lysine hydroxylation and the intermolecular cross-link profile. The increased hydroxylation and change in cross-linking are consistent with increased turnover of the collagen, possibly in an attempt to initiate a repair mechanism which, in fact, leads to an acceleration in the increase in fragility of the bone. Clearly there are post-translational modifications of the newly synthesized collagen in avian osteoporosis, and these changes may play a role in the pathogenesis of the disease.