Predictive value of serum actin-free Gc-globulin for complications and outcome in acute liver failure
Predictive value of serum actin-free Gc-globulin for complications and outcome in acute liver failure
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DOI：
10.1111/jvh.12259
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发表时间：
2015-02-01
影响因子：
2.5
通讯作者：
Kar, P.
中科院分区：
文献类型：
--
作者：
Bagchi, A.;Kumar, S.;Kar, P.
这项前瞻性研究旨在评估早期无肌动蛋白GC球蛋白水平的变化是否与并发症和预后相关，并确定与急性肝功能衰竭(ALF)持续低水平无肌动蛋白GC球蛋白水平相关的因素。对2011年10月至2012年12月收治的32例ALF患者进行随访，直至死亡或完全恢复。所有患者均在入院时、入院第3天或到期时进行血清无肌动蛋白GC-球蛋白测定。采用Logistic回归分析确定影响死亡率的独立预测因素。还进行了接收器工作特性曲线分析。死亡患者的无肌动蛋白GC球蛋白水平中位数显著低于存活患者(87.32vs180 mg/L；P<；0.001)。受试者工作特征曲线分析显示曲线下面积为0.771，并显示血清无肌动蛋白GC球蛋白水平。
This prospective study was designed to evaluate whether early changes in actin-free Gc-globulin levels were associated with complications and outcomes and to identify factors associated with persistent low actin-free Gc-globulin levels in acute liver failure (ALF). Thirty-two consecutive ALF patients admitted from October 2011 to December 2012 were followed up until death or complete recovery. All had serum actin-free Gc-globulin estimation at admission and at day three or expiry. Logistic regression analysis was performed to identify independent predictors of mortality. A receiver operating characteristic curve analysis was also performed. Nonsurvivors had significantly lower median actin-free Gc-globulin levels than survivors (87.32 vs 180 mg/L; P < 0.001). A receiver operating characteristic curve analysis revealed an area under curve (AUC) of 0.771 and showed that serum actin-free Gc-globulin level of