PET Tracers Beyond FDG in Prostate Cancer.
PET Tracers Beyond FDG in Prostate Cancer.
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前列腺癌中 PET 示踪剂超越 FDG。
DOI：
10.1053/j.semnuclmed.2016.07.005
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发表时间：
2016-11
影响因子：
4.9
通讯作者：
Fanti S
中科院分区：
文献类型：
--
作者：
Schuster DM;Nanni C;Fanti S
传统的解剖成像与计算机断层扫描（CT）和磁共振成像（MRI）在前列腺癌的评价有局限性。正电子发射断层扫描（PET）是一种功能强大的成像技术，可以直接针对不同的分子靶点，如葡萄糖代谢，前列腺特异性膜抗原（PSMA）受体的密度和骨骼成骨细胞活性。虽然2-脱氧-2-[18 F]氟脱氧葡萄糖（FDG）PET是分子成像的支柱，但FDG在典型的惰性前列腺癌中具有局限性。然而，除了FDG之外，还有许多有用的和新兴的PET示踪剂提供附加值。这些包括通过与胆碱、乙酸盐、氨基酸、蛙皮素、双氢睾酮等生物学相关的分子机制来询问前列腺癌的放射性示踪剂。胆碱用于细胞膜合成，其代谢在前列腺癌中上调。11 C-胆碱和18F-胆碱在美国以外的临床上广泛使用，并且已被证明对检测复发性前列腺癌最有益。11 C-乙酸盐是脂肪酸合成的间接生物标志物，其在前列腺癌中也上调。用11 C-醋酸盐对前列腺癌进行成像总体上与胆碱放射性示踪剂相似，但没有广泛使用。前列腺癌中氨基酸转运的上调为基于氨基酸的放射性示踪剂提供了生物学基础。最新的进展是使用非天然脂环族氨基酸类似物放射性示踪剂抗1-氨基-3-18 F-氟环丁烷-1-羧酸（FACBC或氟昔洛韦），也被证明对检测复发性前列腺癌最有用。其他新兴的前列腺癌PET放射性示踪剂包括针对胃泌素释放肽受体（GRPR）的蛙皮素组、与雄激素受体结合的16β-18 F-氟-5 α-二氢睾酮（FDHT），以及靶向血管活性肠多肽受体1（VPAC-1）和尿激酶纤溶酶原激活物受体（uPAR）的放射性示踪剂，这些受体也在前列腺癌中过表达。
Conventional anatomic imaging with computed tomography (CT) and magnetic resonance imaging (MRI) has limitations in the evaluation of prostate cancer. Positron emission tomography (PET) is a powerful imaging technique which can be directed toward molecular targets as diverse as glucose metabolism, density of prostate specific membrane antigen (PSMA) receptors, and skeletal osteoblastic activity. While 2-deoxy-2-[18F]fluorodeoxyglucose (FDG) PET is the mainstay of molecular imaging, FDG has limitations in typically indolent prostate cancer. Yet, there are many useful and emerging PET tracers beyond FDG which provide added value. These include radiotracers interrogating prostate cancer via molecular mechanisms related to the biology of choline, acetate, amino acids, bombesin, dihydrotestosterone, among others. Choline is utilized for cell membrane synthesis and its metabolism is upregulated in prostate cancer. 11C-choline and 18F-choline are in wide clinical use outside the United States, and have proven most beneficial for detection of recurrent prostate cancer. 11C-acetate is an indirect biomarker of fatty acid synthesis which is also upregulated in prostate cancer. Imaging of prostate cancer with 11C-acetate is overall similar to the choline radiotracers yet is not as widely utilized. Upregulation of amino acid transport in prostate cancer provides the biologic basis for amino acid based radiotracers. Most recent progress has been made with the non-natural alicyclic amino acid analogue radiotracer anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid (FACBC or fluciclovine) also proven most useful for the detection of recurrent prostate cancer. Other emerging PET radiotracers for prostate cancer include the bombesin group directed to the gastrin releasing peptide receptor (GRPR), 16β-18F-fluoro-5α-dihydrotestosterone (FDHT) which binds to the androgen receptor, and those targeting the vasoactive intestinal polypeptide receptor 1 (VPAC-1) and urokinase plasminogen activator receptor (uPAR) which are also overexpressed in prostate cancer.
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DOI：
10.1007/s00259-014-2872-x
发表时间：
2014-12-01
影响因子：
9.1
作者：
Ceci, Francesco;Herrmann, Ken;Fanti, Stefano
通讯作者：
Fanti, Stefano
影响因子：
23.4
作者：
Briganti, Alberto;Chun, Felix K. -H.;Karakiewicz, Pierre I.
通讯作者：
Karakiewicz, Pierre I.
影响因子：
2.1
作者：
Chuaqui, RF;Englert, CR;EmmertBuck, MR
通讯作者：
EmmertBuck, MR
影响因子：
6.6
作者：
Cagiannos, I;Karakiewicz, P;Kattan, MW
通讯作者：
Kattan, MW
DOI：
10.2967/jnumed.109.066159
发表时间：
2010-02
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Beattie BJ;Smith-Jones PM;Jhanwar YS;Schöder H;Schmidtlein CR;Morris MJ;Zanzonico P;Squire O;Meirelles GS;Finn R;Namavari M;Cai S;Scher HI;Larson SM;Humm JL
通讯作者：
Humm JL