MILD SENILE DEMENTIA OF THE ALZHEIMER TYPE .4. EVALUATION OF INTERVENTION
MILD SENILE DEMENTIA OF THE ALZHEIMER TYPE .4. EVALUATION OF INTERVENTION
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DOI：
10.1002/ana.410310303
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发表时间：
1992-03-01
影响因子：
11.2
通讯作者：
FIGIEL, G
中科院分区：
文献类型：
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作者：
BERG, L;MILLER, JP;FIGIEL, G
旨在减缓或阻止阿尔茨海默型老年性痴呆进展的干预试验的设计必须基于对疾病自然史的分析。使用随机系数的统计模型，我们分析了自然历史的阿尔茨海默氏症型老年痴呆症在仔细定义的受试者轻度疾病（n = 68）的时间长达10年。受试者的表现进行了评估纵向电池的临床和心理测量。这些措施的特点进行了分析相关的效用作为长期试验的阿尔茨海默型老年痴呆症患者的结局措施。估计了显示停滞所需的样本量，以及轻度疾病进展减慢50%或25%。我们建议，临床相关的全球措施，如临床痴呆症评定量表的方框总和，和基于性能的临床量表或心理测量将是适当的，在12个月或24个月的试验招募轻度老年痴呆症的阿尔茨海默型的受试者。
The design of trials of interventions intended to slow or arrest the progression of senile dementia Of the Alzheimer type must be based on analysis of the natural history of the disease. Using a random coefficients statistical model, we analyzed the natural history of senile dementia of the Alzheimer type in carefully defined subjects with mild disease (n = 68) for periods of up to 10 years. Subject performance was assessed longitudinally on batteries of clinical and psychometric measures. The characteristics of these measures were analyzed relevant to their utility as outcome measures for long-term trials in patients with senile dementia of the Alzheimer type. Estimates were made of sample sizes required to show arrest, and 50% or 25% slowing in the progression of mild disease. We suggest that a clinically relevant global measure, such as the Sum of Boxes of the Clinical Dementia Rating scale, and a performance-based clinical scale or psychometric measure would be appropriate in a 12- or 24-month trial enrolling subjects with mild senile dementia of the Alzheimer type.