Disruption of Visuospatial and Somatosensory Functional Connectivity in Anorexia Nervosa
Disruption of Visuospatial and Somatosensory Functional Connectivity in Anorexia Nervosa
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DOI：
10.1016/j.biopsych.2012.04.025
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发表时间：
2012-11-15
影响因子：
10.6
通讯作者：
Di Salle, Francesco
中科院分区：
文献类型：
--
作者：
Favaro, Angela;Santonastaso, Paolo;Di Salle, Francesco
背景：虽然身体意象障碍被认为是神经性厌食症（AN）的核心特征之一，但人们对这种复杂特征的确切性质知之甚少。与任务相关的功能磁共振成像研究只能部分探索身体意识的多模态复杂性，这是一种以视觉感知、本体感觉和触觉等方面为基础的复杂认知。本研究的目的是探索 AN 中涉及视觉空间和体感处理的网络的功能连接。方法：29 名 AN 受试者、16 名已康复的女性和 26 名健康女性接受静息态功能磁共振成像扫描，并使用 Rey-Osterrieth 复杂图形测试对其视觉空间能力进行神经心理学评估。结果：两个 AN 组均显示腹侧连接性下降的区域视觉网络，一个涉及“什么？”的网络。视觉感知的途径。更有趣的是，即使在没有视觉信息的情况下，AN 组（而非恢复的 AN 组）的左顶叶皮层（包括体感皮层）的共激活增加，该区域涉及长期多模态空间记忆和表征。对视觉空间能力的神经心理学评估显示，细节处理和全局整合（中央一致性）方面显示出 AN 组中该大脑区域的连接性相关。结论：我们的研究结果表明，AN 与大脑连接的双重破坏有关，这显示出与视觉空间困难的特定关联，并可能解释可能维持身体图像干扰的视觉和体感知觉信息之间的整合过程的失败。
Background: Although body image disturbance is considered one of the core characteristics of anorexia nervosa (AN), the exact nature of this complex feature is poorly understood. Task-related functional magnetic resonance imaging studies can only partially explore the multimodal complexity of body consciousness, which is a complex cognition underpinned by aspects of visual perception, proprioception, and touch. The aim of the present study was to explore the functional connectivity of networks involved in visuospatial and somatosensory processing in AN.Methods: Twenty-nine subjects with AN, 16 women who had recovered from it, and 26 healthy women underwent a resting-state functional magnetic resonance imaging scan and neuropsychological assessment of their visuospatial abilities using the Rey-Osterrieth Complex Figure Test.Results: Both AN groups showed areas of decreased connectivity in the ventral visual network, a network involved in the "what?" pathway of visual perception. Even more interestingly, the AN group, but not the recovered AN group, displayed increased coactivation in the left parietal cortex, encompassing the somatosensory cortex, in an area implicated in long-term multimodal spatial memory and representation, even in the absence of visual information. A neuropsychological assessment of visuospatial abilities revealed that aspects of detail processing and global integration (central coherence) showed correlations with connectivity of this brain area in the AN group.Conclusions: Our findings show that AN is associated with double disruption of brain connectivity, which shows a specific association with visuospatial difficulties and may explain the failure of the integration process between visual and somatosensory perceptual information that might sustain body image disturbance.