Women Taking a Folic Acid Supplement in Countries with Mandatory Food Fortification Programs May Be Exceeding the Upper Tolerable Limit of Folic Acid: A Systematic Review.
Women Taking a Folic Acid Supplement in Countries with Mandatory Food Fortification Programs May Be Exceeding the Upper Tolerable Limit of Folic Acid: A Systematic Review.
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背景：在未孕和怀孕期间，妇女被鼓励在食物摄入量之外补充叶酸。叶酸的耐受上限是每天1000微克；然而，确定这个水平是为了避免掩盖维生素B12缺乏，而不是基于叶酸的生物利用度和新陈代谢。这项综述的目的是评估在高收入国家实施叶酸食品强化计划的育龄妇女和怀孕期间叶酸的总摄入量。方法：在五个数据库中进行系统搜索，寻找自1998年以来发表的报告了强制强化政策国家的叶酸和叶酸摄入量的研究。结果：即使在食用强化食品时，育龄妇女也不能单独从食物来源获得足够的叶酸摄入量；然而，几乎所有服用叶酸补充剂的妇女都超过了叶酸摄入量的上限。结论：叶酸补充建议和政策制定者设定的1000微克的上限值得仔细审查，以考虑到超过上限对叶酸吸收和代谢的潜在不利影响，以及随后对育龄妇女健康的影响。
Background: In preconception and pregnancy, women are encouraged to take folic acid-based supplements over and above food intake. The upper tolerable limit of folic acid is 1000 mcg per day; however, this level was determined to avoid masking a vitamin B12 deficiency and not based on folic acid bioavailability and metabolism. This review’s aim is to assess the total all-source intake of folate in women of childbearing age and in pregnancy in high-income countries with folate food fortification programs. Methods: A systematic search was conducted in five databases to find studies published since 1998 that reported folate and folic acid intake in countries with a mandatory fortification policy. Results: Women of childbearing age do not receive sufficient folate intake from food sources alone even when consuming fortified food products; however, almost all women taking a folic acid-based supplement exceed the upper tolerable limit of folic acid intake. Conclusions: Folic acid supplement recommendations and the upper tolerable limit of 1000 mcg set by policy makers warrant careful review in light of potential adverse effects of exceeding the upper tolerable limit on folic acid absorption and metabolism, and subsequent impacts on women’s health during their childbearing years.
影响因子：
3.7
作者：
Gupta N;Sarkar S;David A;Gangwar PK;Gupta R;Khanna G;Sankhwar SN;Khanna A;Rajender S
通讯作者：
Rajender S