3D mapping of oxygen and CO2 transport rates in the lung: a new imaging tool for use in lung surgery, intensive care and basic research.
3D mapping of oxygen and CO2 transport rates in the lung: a new imaging tool for use in lung surgery, intensive care and basic research.
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肺部氧气和二氧化碳传输速率的 3D 绘图：一种用于肺部手术、重症监护和基础研究的新型成像工具。
DOI：
10.1080/17476348.2016.1206818
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发表时间：
2016
影响因子：
3.9
通讯作者：
Venegas,JoseGabriel
中科院分区：
文献类型：
--
作者：
Johansen,Troels;Venegas,JoseGabriel
在临床上，术语肺气体交换用于描述广泛的整体和区域生理测量。全局测量旨在通过使用单个输出参数（例如，动脉血气O2（PaO 2）和CO2（PaCO 2）的压力、总O2摄取或CO2消除，或通气/灌注（V/Q）分布参数）来表征患者的一般气体交换状态，可以说，这使得它们易于应用于诊断。它们的缺点是，它们没有提供关于肺内不同解剖单元对气体交换的贡献程度的空间信息。相比之下，通过成像区域通气、灌注和V/Q提供的数据提供了影响患者气体交换状态的生理因素的更详细的图片，但往往更难以解释。也许正是由于这个原因，V/Q成像通常仅限于少数临床应用（诊断肺栓塞和慢性阻塞性肺疾病（COPD）和肺癌的术前筛查是主要的）。在肺生理学中，术语区域气体交换经常被用作区域V/Q比的同义词。虽然V/Q的局部值确实是局部毛细血管末端和肺泡O2和CO2水平的重要决定因素，但它不能用作局部气体交换速率的替代物，并且不可能仅基于V/Q的局部值来推断不同肺区域对整体气体交换的功能贡献。1
Clinically, the term Lpulmonary gas exchangeT is used to describe a wide range of global and regional physiological measurements. Global measurements aspire to characterize the general gas exchange status of the patient by using single output parameters (eg arterial blood gas tensions of O2 (PaO2) and CO2 (PaCO2), total O2 uptake or CO2 elimination, or ventilation/perfusion (V/Q) distribution parameters), arguably making them easy to apply diagnostically. Their shortcoming is that they provide no spatial information on how well different anatomical units within the lung are contributing to gas exchange. In contrast, the data provided by imaging regional ventilation, perfusion, and V/Q provide a more detailed picture of the physiological factors affecting the patientLs gas exchange state but tend to be more difficult to interpret. It is perhaps for that reason that V/Q imaging has generally been restricted to a small number of clinical applications (diagnosing pulmonary embolisms and presurgical screening in chronic obstructive pulmonary disease (COPD) and lung cancer being the primary ones).In pulmonary physiology, the term regional gas exchange is very often used as a synonym of regional V/Q ratio. While it is true that the local value of V/Q is an important determinant of local end-capillary and alveolar O2 and CO2 levels, it cannot be used as a surrogate for the local rates of gas exchange, and it is not possible to infer the functional contribution of different lung regions to global gas exchange exclusively based on local values of V/Q. 1