Sexual dimorphism of cardiometabolic dysfunction: Gut microbiome in the play?
Sexual dimorphism of cardiometabolic dysfunction: Gut microbiome in the play?
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DOI：
10.1016/j.molmet.2018.05.016
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发表时间：
2018-09
影响因子：
8.1
通讯作者：
Rey FE
中科院分区：
文献类型：
--
作者：
Cross TL;Kasahara K;Rey FE
Sex is one of the most powerful modifiers of disease development. Clear sexual dimorphism exists in cardiometabolic health susceptibility, likely due to differences in sex steroid hormones. Changes in the gut microbiome have been linked with the development of obesity, type 2 diabetes, and atherosclerosis; however, the impact of microbes in sex-biased cardiometabolic disorders remains unclear. The gut microbiome is critical for maintaining a normal estrous cycle, testosterone levels, and reproductive function. Gut microbes modulate the enterohepatic recirculation of estrogens and androgens, affecting local and systemic levels of sex steroid hormones. Gut bacteria can also generate androgens from glucocorticoids. This review summarizes current knowledge of the complex interplay between sexual dimorphism in cardiometabolic disease and the gut microbiome. Emerging evidence suggests the role of gut microbiome as a modifier of disease susceptibility due to sex; however, the impact on cardiometabolic disease in this complex interplay is lacking. Elucidating the role of gut microbiome on sex-biased susceptibility in cardiometabolic disease is of high relevance to public health given its high prevalence and significant financial burden.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
5.8
作者：
ADLERCREUTZ, H;MARTIN, F;TIKKANEN, MJ
通讯作者：
TIKKANEN, MJ
影响因子：
24.5
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Cani PD;Possemiers S;Van de Wiele T;Guiot Y;Everard A;Rottier O;Geurts L;Naslain D;Neyrinck A;Lambert DM;Muccioli GG;Delzenne NM
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Delzenne NM
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4.5
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Bennett BJ;Davis RC;Civelek M;Orozco L;Wu J;Qi H;Pan C;Packard RR;Eskin E;Yan M;Kirchgessner T;Wang Z;Li X;Gregory JC;Hazen SL;Gargalovic PS;Lusis AJ
通讯作者：
Lusis AJ
影响因子：
168.9
作者：
Charchar, Fadi J.;Bloomer, Lisa D. S.;Barnes, Timothy A.;Cowley, Mark J.;Nelson, Christopher P.;Wang, Yanzhong;Denniff, Matthew;Debiec, Radoslaw;Christofidou, Paraskevi;Nankervis, Scott;Dominiczak, Anna F.;Bani-Mustafa, Ahmed;Balmforth, Anthony J.;Hall, Alistair S.;Erdmann, Jeanette;Cambien, Francois;Deloukas, Panos;Hengstenberg, Christian;Packard, Chris;Schunkert, Heribert;Ouwehand, Willem H.;Ford, Ian;Goodall, Alison H.;Jobling, Mark A.;Samani, Nilesh J.;Tomaszewski, Maciej
通讯作者：
Tomaszewski, Maciej