Perfluorooctyl bromide concentration in plasma and tissues of beagle dogs.
Perfluorooctyl bromide concentration in plasma and tissues of beagle dogs.
复制标题
比格犬血浆和组织中的全氟辛基溴浓度。
DOI：
10.1002/jps.2600670751
复制
发表时间：
1978
影响因子：
3.8
通讯作者：
J. Edelson
中科院分区：
文献类型：
--
作者：
F. H. Lee;M. Scrime;J. Edelson
在给比格犬以30.8 g/kg或3.9 g/kg的剂量气管内注射单剂量全氟辛基溴后，经常测定血浆水平。终末消除期的一级表观半衰期为口服给药后约1天，气管内给药后约7天。组织分析显示，4周后解剖的狗腹部脂肪中化合物的浓度最高。
Plasma levels were determined frequently after single doses of perfluorooctyl bromide were administered to beagle dogs at doses of either 30.8 g/kg po or 3.9 g/kg intratracheally. The apparent first-order half-life during the terminal elimination phase was about 1 day after oral medication and about 7 days after intratracheal administration. Analysis of tissues revealed the highest concentrations of the compound in abdominal fat of dogs autopsied 4 weeks later.