The Effect of Maternal Obesity on Breast Milk Fatty Acids and Its Association with Infant Growth and Cognition-The PREOBE Follow-Up
The Effect of Maternal Obesity on Breast Milk Fatty Acids and Its Association with Infant Growth and Cognition-The PREOBE Follow-Up
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DOI：
10.3390/nu11092154
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发表时间：
2019-09-01
期刊：
影响因子：
5.9
通讯作者：
Carmen Lopez-Sabater, M.
中科院分区：
文献类型：
--
作者：
de la Garza Puentes, Andrea;Marti Alemany, Adria;Carmen Lopez-Sabater, M.
本研究分析了母亲肥胖如何影响母乳中的脂肪酸(FAs)及其与婴儿生长和认知的关系，以提高人们对母亲健康规划效果的认识，并促进健康的产前体重。78对母子按孕前体重指数(BMI)分组：正常体重(BMI=18.5~24.99)、超重(BMI=25~29.99)和肥胖(BMI>；30)。测定初乳和成熟乳中FAs。分析婴儿6个月、18个月和36个月时的体格测量和18个月时的认知能力。成熟牛奶的花生四烯酸(AA)和二十二碳六烯酸(DHA)等含量低于初乳。非正常体重母亲乳汁中饱和脂肪酸和n6：n3比值升高，α-亚麻酸(ALA)、DHA和单不饱和脂肪酸降低。6个月大的婴儿体重指数与初乳n6(如AA)和n3(如DHA)脂肪酸呈负相关，与n6：n3比率呈正相关。母乳亚油酸、n6PUFAs、ALA、DHA和n3LC-PUFAs对婴儿认知有正向影响，而n6：n3比对婴儿认知有负向影响。总而言之，这项研究表明，孕前母亲的BMI会影响母乳FAs和婴儿的发育和认知，从而证实了健康体重在后代中的重要性。
This study analyzed how maternal obesity affected fatty acids (FAs) in breast milk and their association with infant growth and cognition to raise awareness about the programming effect of maternal health and to promote a healthy prenatal weight. Mother-child pairs (n = 78) were grouped per maternal pre-pregnancy body mass index (BMI): normal-weight (BMI = 18.5-24.99), overweight (BMI = 25-29.99) and obese (BMI > 30). Colostrum and mature milk FAs were determined. Infant anthropometry at 6, 18 and 36 months of age and cognition at 18 were analyzed. Mature milk exhibited lower arachidonic acid (AA) and docosahexaenoic acid (DHA), among others, than colostrum. Breast milk of non-normal weight mothers presented increased saturated FAs and n6:n3 ratio and decreased alpha-linolenic acid (ALA), DHA and monounsaturated FAs. Infant BMI-for-age at 6 months of age was inversely associated with colostrum n6 (e.g., AA) and n3 (e.g., DHA) FAs and positively associated with n6:n3 ratio. Depending on the maternal weight, infant cognition was positively influenced by breast milk linoleic acid, n6 PUFAs, ALA, DHA and n3 LC-PUFAs, and negatively affected by n6:n3 ratio. In conclusion, this study shows that maternal pre-pregnancy BMI can influence breast milk FAs and infant growth and cognition, endorsing the importance of a healthy weight in future generations.