Rational Designs of Biomaterials for Combating Oral Biofilm Infections
Rational Designs of Biomaterials for Combating Oral Biofilm Infections
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DOI：
10.1002/adma.202305633
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Cui Huang
中科院分区：
文献类型：
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作者：
Zhengrong Yin;Yaxi Liu;Annikaer Anniwaer;Yuan You;Jingmei Guo;Ying Tang;Lei Fu;Luyao Yi;Cui Huang
AbstractOral biofilms, which are also known as dental plaque, are the culprit of a wide range of oral diseases and systemic diseases, thus contributing to serious health risks. The manner of how to achieve good control of oral biofilms has been an increasing public concern. Novel antimicrobial biomaterials with highly controllable fabrication and functionalization have been proven to be promising candidates. However, previous reviews have generally emphasized the physicochemical properties, action mode, and application effectiveness of those biomaterials, whereas insufficient attention has been given to the design rationales tailored to different infection types and application scenarios. To offer guidance for better diversification and functionalization of anti‐oral‐biofilm biomaterials, this review details the up‐to‐date design rationales in three aspects: the core strategies in combating oral biofilm, as well as the biomaterials with advanced antibiofilm capacity and multiple functions based on the improvement or combination of the abovementioned antimicrobial strategies. Thereafter, insights on the existing challenges and future improvement of biomaterial‐assisted oral biofilm treatments are proposed, hoping to provide a theoretical basis and reference for the subsequent design and application of antibiofilm biomaterials.This article is protected by copyright. All rights reserved
