A magnetic resonance (MR) compatible selective brain temperature manipulation system for preclinical study.
A magnetic resonance (MR) compatible selective brain temperature manipulation system for preclinical study.
复制标题
DOI：
10.2147/mder.s26835
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
An H
中科院分区：
文献类型：
--
作者：
Liu Q;Cai Y;Lin W;Turner GH;An H
有压倒性的证据表明，低温可以改善缺血性中风的结果。然而，目前使用最广泛的系统性冷却方法可能导致多种副作用，而目前的选择性冷却方法与磁共振成像的不兼容性极大地限制了其在临床前研究中的应用。在本研究中，我们开发了一种磁共振兼容的小动物选择性脑温度操纵系统，该系统可以在保持正常身体生理状态的同时，快速准确地调节脑温度。利用该装置检测缺血性脑卒中磁共振成像时T1弛豫、脑血流量和脑组织温度的关系。结果表明，该装置可作为一种有效的脑温度控制工具，用于需要局部低温或高温条件的临床前研究。
There is overwhelming evidence that hypothermia can improve the outcome of an ischemic stroke. However, the most widely used systemic cooling method could lead to multiple side effects, while the incompatibility with magnetic resonance imaging of the present selective cooling methods highly limit their application in preclinical studies. In this study, we developed a magnetic resonance compatible selective brain temperature manipulation system for small animals, which can regulate brain temperature quickly and accurately for a desired period of time, while maintaining the normal body physiological conditions. This device was utilized to examine the relationship between T1 relaxation, cerebral blood flow, and temperature in brain tissue during magnetic resonance imaging of ischemic stroke. The results showed that this device can be an efficient brain temperature manipulation tool for preclinical studies needing local hypothermic or hyperthermic conditions.