Evaluating the InterVA model for determining AIDS mortality from verbal autopsies in the adult population of Addis Ababa
Evaluating the InterVA model for determining AIDS mortality from verbal autopsies in the adult population of Addis Ababa
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DOI：
10.1111/j.1365-3156.2010.02484.x
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发表时间：
2010-05-01
影响因子：
3.3
通讯作者：
Reniers, Georges
中科院分区：
文献类型：
--
作者：
Tensou, Biruk;Araya, Tekebash;Reniers, Georges
P> Objective-evaluate a verbal autopsy（VA）expert algorithm（the InterVA model）for diagnosing AIDS mortality against a reference standard from hospital records that including HIV serostatus information in阿迪斯Ababa，Ethiopia.MethodsVerbal autopsy were conducted for 193 individuals who visited a hospital under monitoring during terminal disease.死者入院诊断和艾滋病毒血清状态信息用于构建两个参考标准（艾滋病与其他死因和结核病/艾滋病与其他死因）。InterVA模型被用来解释VA的采访，并计算的灵敏度，特异性和原因特异性死亡率分数的InterVA model.ResultsThe诊断艾滋病的InterVA模型的诊断准确性的指标为0.82（95%CI：0.74-0.89）和0.76（95%CI：0.64-0.86），分别。对结核病/艾滋病的敏感性和特异性分别为0.91（95% CI：0.85-0.96）和0.78（95% CI：0.63-0.89）。该模型估计的艾滋病特异性死亡率分数为61.7%（95% CI：54-69%），接近参考标准的64.7%（95% CI：57-72%）。该模型估计的结核病/艾滋病死亡率为73.6%（95%CI：67-80%），而参考标准为74.1%（95%CI：68-81%）。结论InterVA模型是一种易于使用且廉价的医生审查替代方案，用于评估没有生命登记和死因医学证明的人群的艾滋病死亡率。当结核病和艾滋病结合在一起时，该模型似乎表现得更好，但样本太小，无法从统计学上证实这一点。
P>ObjectiveTo evaluate the performance of a verbal autopsy (VA) expert algorithm (the InterVA model) for diagnosing AIDS mortality against a reference standard from hospital records that include HIV serostatus information in Addis Ababa, Ethiopia.MethodsVerbal autopsies were conducted for 193 individuals who visited a hospital under surveillance during terminal illness. Decedent admission diagnosis and HIV serostatus information are used to construct two reference standards (AIDS vs. other causes of death and TB/AIDS vs. other causes). The InterVA model is used to interpret the VA interviews; and the sensitivity, specificity and cause-specific mortality fractions are calculated as indicators of the diagnostic accuracy of the InterVA model.ResultsThe sensitivity and specificity of the InterVA model for diagnosing AIDS are 0.82 (95% CI: 0.74-0.89) and 0.76 (95% CI: 0.64-0.86), respectively. The sensitivity and specificity for TB/AIDS are 0.91 (95% CI: 0.85-0.96) and 0.78 (95% CI: 0.63-0.89), respectively. The AIDS-specific mortality fraction estimated by the model is 61.7% (95% CI: 54-69%), which is close to 64.7% (95% CI: 57-72%) in the reference standard. The TB/AIDS mortality fraction estimated by the model is 73.6% (95% CI: 67-80%), compared to 74.1% (95% CI: 68-81%) in the reference standard.ConclusionThe InterVA model is an easy to use and cheap alternative to physician review for assessing AIDS mortality in populations without vital registration and medical certification of causes of death. The model seems to perform better when TB and AIDS are combined, but the sample is too small to statistically confirm that.