Atypical Vestibular Neuritis: A Case Report
Atypical Vestibular Neuritis: A Case Report
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非典型前庭神经炎：病例报告
DOI：
10.1016/s0194-59989570185-0
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
P. Fagan
中科院分区：
文献类型：
--
作者：
Fenton John E.;A. Shirazi;J. Turner;P. Fagan
讨论本病例报告中最重要的发现是获得了前庭神经炎症的组织学证据。前庭耳蜗神经炎的诊断是持续的，因为耳蜗神经也被发现有炎性浸润物，尽管它不像前庭受累那么广泛。要得出的第一个结论是第八颅神经确实发生了炎症。大多数文献都认为VN的病因与病毒感染有关。2-4大多数作者支持VN的病毒理论，其基础是40%的患者以前有过病毒感染，1与报告的耳带状疱疹病例相似，3以及VN在病毒流行中的发病率增加？这些病毒理论的支持者没有组织学证据来支持他们的说法。对这篇文章中的标本进行了彻底的组织病理学评估，没有发现病毒原因的证据。组织学发现与慢性炎症相一致，没有任何迹象表明是脉管炎或肉芽肿原因。这种对患病神经本身的深入分析
DISCUSSIONThe most important finding in this case report is that histologic evidence of an inflammation of the vestibular nerve was obtained. A diagnosis of vestibulocochlear neuritis is sustained because the cochlear nerve was also found to have an inflammatory infiltrate, although it was not as extensive as the vestibular involvement. The first conclusion to be drawn is that inflammation of the eighth cranial nerve does occur. A viral infection has been implicated in the cause of VN by most papers. 2-4 Most authors favor a viral theory with VN on the basis of a preceding viral infection in 40% of patients, 1 on the similarity to a reported case of herpes zoster oticus, 3 and also on the reported increased incidence of VN in viral epidemics? These proponents of a viral theory do not have histologic evidence to support their claim. A thorough histopathologic assessment of the specimens in this article revealed no evidence for a viral cause. The histologic findings were consistent with chronic inflammation, and there was nothing to suggest either a vasculitic or granulomatous cause. This in-depth analysis of the diseased nerve itself