Psychopharmacological treatment of disruptive behavior in youths: systematic review and network meta-analysis.
Psychopharmacological treatment of disruptive behavior in youths: systematic review and network meta-analysis.
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DOI：
10.1038/s41598-023-33979-2
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发表时间：
2023-04-28
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
对各种精神药物治疗青少年破坏性行为（DBs）的疗效进行系统评价。为此，我们系统地回顾了针对DBs症状的各种精神药物的随机临床试验（RCT），并应用网络荟萃分析来研究它们的相对疗效。选择了符合纳入标准的55项RCT。为了预测和解释相对的治疗效果，我们根据其作用机制比较了各种精神药物对DB症状的疗效。网络荟萃分析显示，对于减少DB，第二代抗精神病药，兴奋剂和非兴奋剂ADHD药物比安慰剂更有效，第二代抗精神病药是最有效的。本文就这些药物对自上而下抑制过程的多巴胺能调节进行综述。这项研究提供了各种精神药物治疗DB的相对疗效的信息，并深入了解这些症状的潜在神经生物学基础。它还说明了这些神经生物学机制作为未来治疗研究目标的潜在效用。
To conduct a systematic review of the comparative efficacy of various psychotropic medications for the treatment of disruptive behavior (DBs) in youths. To this aim, we systematically reviewed randomized clinical trials (RCTs) of various psychotropic medications targeting symptoms of DBs and applied network meta-analysis to investigate their relative efficacy. Fifty-five RCTs meeting the inclusion criteria were selected. To predict and interpret relative treatment efficacy, we compared the efficacy of various psychotropic medications prescribed for DB symptoms based on their mechanism of action. Network meta-analysis revealed that for reducing DBs, second-generation antipsychotics, stimulants, and non-stimulant ADHD medications were more efficacious than placebo, and second-generation antipsychotics were the most efficacious. The dopaminergic modulation of top-down inhibitory process by these medications is discussed in this review. This study offers information on the relative efficacy of various psychotropic medications for the treatment of DB, and insight into a potential neurobiological underpinning for those symptoms. It also illustrates the potential utility of these neurobiological mechanisms as a target for future treatment studies.
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影响因子：
8
作者：
Bangs, Mark E.;Hazell, Philip;Levine, Louise
通讯作者：
Levine, Louise
影响因子：
5.6
作者：
Dell'Agnello, Grazia;Maschietto, Dino;Zuddas, Alessandro
通讯作者：
Zuddas, Alessandro
影响因子：
168.9
作者：
Cipriani, Andrea;Zhou, Xinyu;Xie, Peng
通讯作者：
Xie, Peng
影响因子：
3.7
作者：
Buhle, Jason T.;Silvers, Jennifer A.;Ochsner, Kevin N.
通讯作者：
Ochsner, Kevin N.
DOI：
10.1089/1044546041649020
发表时间：
2004-06-01
影响因子：
1.9
作者：
Aman, MG;Binder, C;Turgay, A
通讯作者：
Turgay, A