Associations Between Headache-Free Days and Patient-Reported Outcomes Among Migraine Patients: A Cross-Sectional Analysis of Survey Data in Europe
Associations Between Headache-Free Days and Patient-Reported Outcomes Among Migraine Patients: A Cross-Sectional Analysis of Survey Data in Europe
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DOI：
10.1007/s40122-019-0133-1
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发表时间：
2019-12-01
期刊：
影响因子：
4
通讯作者：
Fang, Juanzhi
中科院分区：
文献类型：
--
作者：
Doane, Michael J.;Gupta, Shaloo;Fang, Juanzhi
偏头痛给患者、社会和医疗保健系统带来了巨大的负担。本研究旨在评估欧盟5国（法国、德国、意大利、西班牙和英国）偏头痛患者无头痛天数（HFDs）与健康相关生活质量（HRQoL）、工作效率和活动障碍（WPAI）以及医疗资源利用率（HRU）之间的关系。方法本回顾性横断面研究收集了2017年全国健康与健康调查（N=62,000）中年龄在bb0 = 18岁的成年人的调查反馈。经医生诊断为偏头痛且在前一个月至少有4个月头痛日的偏头痛患者被纳入研究（N=1569）。比较偏头痛患者HFDs数与短表12项量表第2版（SF-12v2）身心成分综合评分（PCS和MCS）、短表6d （SF-6D）和EuroQoL-5D （EQ-5D）评分、WPAI和HRU。相关分析用于检验双变量相关性，而广义线性模型用于多变量分析。结果每增加1个HFD， MCS、PCS、SF-6D效用评分和EQ-5D指数评分分别平均增加0.171、0.306、0.003和0.008分（p < 0.05）
IntroductionMigraine imposes a substantial burden on patients, society, and healthcare systems. This study aimed to assess the associations between the number of headache-free days (HFDs) and health-related quality of life (HRQoL), work productivity and activity impairment (WPAI), and healthcare resource utilization (HRU) in patients with migraine in the EU5 (France, Germany, Italy, Spain, and the United Kingdom).MethodsThis retrospective cross-sectional study collected survey responses from adults aged >= 18 years from the 2017 National Health and Wellness Survey (N=62,000). Migraine patients with a physician's diagnosis of migraine and who had experienced at least 4 monthly headache days in the prior month were included (N=1569). Number of HFDs was compared with Short-Form 12-Item Survey Instrument, version 2 (SF-12v2) physical and mental component summary scores (PCS and MCS), Short-Form-6D (SF-6D) and EuroQoL-5D (EQ-5D) scores, WPAI, and HRU in migraine patients. Correlation analyses were conducted to test the bivariate associations, whereas generalized linear models were used for multivariable analyses.ResultsAn increase of 1 HFD was associated with average increases of 0.171, 0.306, 0.003, and 0.008 points for MCS, PCS, SF-6D utility score, and EQ-5D index score, respectively (p