microRNA as a new immune-regulatory agent in breast milk.
microRNA as a new immune-regulatory agent in breast milk.
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DOI：
10.1186/1758-907x-1-7
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发表时间：
2010-03-01
期刊：
影响因子：
--
通讯作者：
Ochiya T
中科院分区：
文献类型：
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作者：
Kosaka N;Izumi H;Sekine K;Ochiya T
母乳是一种复杂的液体，可为婴儿提供营养并促进婴儿免疫系统的成熟。最近的研究表明，人体体液中存在微小RNA（miRNA）。由于已知 miRNA 可以调节各种免疫系统，因此我们假设人母乳中含有可能对婴儿免疫系统发育很重要的 miRNA。我们分析了人类母乳中 miRNA 的表达情况，并在哺乳期的前 6 个月检测到免疫相关 miRNA 的高表达水平。此外，这些 miRNA 分子即使在非常酸性的条件下也很稳定，这表明母乳允许婴儿从饮食中摄入 miRNA。我们的研究结果为母乳如何调节婴儿免疫系统的发育提供了新的见解。这项研究表明，作为 miRNA 的遗传物质在人与人之间的转移是通过有性生殖以外的方式进行的。
Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Because miRNAs are known to regulate various immune systems, we hypothesized that human breast milk contains miRNAs that may be important for the development of the infant's immune system. We profiled miRNA expression in human breast milk and detected high expression levels of immune-related miRNAs in the first 6 months of lactation. Furthermore, these miRNA molecules are stable even in very acidic conditions, indicating that breast milk allows dietary intake of miRNAs by infants. Our findings provide new insight into how breast milk can modulate the development of the infant's immune system. This study suggests the transfer of genetic material as miRNA from human to human occurs by means other than through sexual reproduction.