GSK-3β, a pivotal kinase in Alzheimer disease.
GSK-3β, a pivotal kinase in Alzheimer disease.
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DOI：
10.3389/fnmol.2014.00046
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发表时间：
2014
影响因子：
4.8
通讯作者：
Avila J
中科院分区：
文献类型：
--
作者：
Llorens-Martín M;Jurado J;Hernández F;Avila J
阿尔茨海默病（AD）是年龄相关性痴呆的最常见形式。AD的病因被认为是多因素的，因为只有可忽略不计的百分比的病例具有家族或遗传起源。糖原合成酶激酶-3（GSK-3）被认为是该疾病的两个组织病理学标志，即老年斑和神经元缠结之间的关键分子联系。在这篇综述中，我们总结了目前有关这种激酶参与AD发展和进展的几个方面的数据，以及强调GSK-3作为AD治疗最相关靶点之一的关键观察结果。
Alzheimer disease (AD) is the most common form of age-related dementia. The etiology of AD is considered to be multifactorial as only a negligible percentage of cases have a familial or genetic origin. Glycogen synthase kinase-3 (GSK-3) is regarded as a critical molecular link between the two histopathological hallmarks of the disease, namely senile plaques and neurofibrillary tangles. In this review, we summarize current data regarding the involvement of this kinase in several aspects of AD development and progression, as well as key observations highlighting GSK-3 as one of the most relevant targets for AD treatment.