Prostate Focused Ultrasound Therapy.
Prostate Focused Ultrasound Therapy.
复制标题
前列腺聚焦超声治疗。
DOI：
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发表时间：
2016
影响因子：
--
通讯作者：
A. Gelet
中科院分区：
文献类型：
--
作者：
J. Chapelon;O. Rouvière;S. Crouzet;A. Gelet
过去 20 年，工程和计算能力与超声换能器技术和成像方式相结合的巨大进步，激发了临床对超声治疗（主要是高强度聚焦超声 (HIFU)）的兴趣的复兴。到目前为止，HIFU 在泌尿外科中获得的最广泛的结果涉及经直肠前列腺消融术，这似乎是恶性前列腺肿瘤患者的有效治疗替代方案。前列腺癌（PCa）是男性最常诊断出的癌症之一。存在多种具有不同治疗方法的治疗选择，包括已使用超过 15 年的用于局部 PCa 的 HIFU。自 2000 年代初以来，已有两种用于此应用的系统上市，其他设备目前正在进行临床试验。 HIFU 治疗可以单独使用，也可以与外照射放疗 (EBRT)（在 HIFU 之前或之后）（之前或之后）结合使用，并且可以重复多次。 HIFU治疗是在超声波实时监测或MRI引导下进行的。今天有两个适应症得到验证：初级保健治疗和 EBRT 失败。 HIFU 用于初级保健治疗的结果与标准适形 EBRT 相似，尽管尚未进行随机比较研究，也没有 HIFU 的 10 年随访数据。 EBRT 失败后 HIFU 的挽救效果随着肿瘤学结果的增加而增加，与手术实现的结果相似，但具有副作用较少的优点。 HIFU 是一项不断发展的技术，非常适合局部治疗。因此，在考虑 PCa 标测技术的准确性和可靠性时，HIFU 局部治疗是必须探索的另一条途径。 HIFU 特别适合这种治疗，因为很明显 HIFU 结果和毒性与治疗的前列腺体积有关。
The tremendous progress in engineering and computing power coupled with ultrasound transducer technology and imaging modalities over the past 20 years have encouraged a revival of clinical interest in ultrasound therapy, mainly in High-Intensity Focused Ultrasound (HIFU). So far, the most extensive results from HIFU obtained in urology involve transrectal prostate ablation, which appears to be an effective therapeutic alternative for patients with malignant prostate tumors. Prostate cancer (PCa) is one of the most frequently diagnosed cancers in men. Several treatment options with different therapeutic approaches exist, including HIFU for localized PCa that has been in use for over 15 years. Since the early 2000s, two systems have been marketed for this application, and other devices are currently in clinical trials. HIFU treatment can be used either alone or in combination with (before- or after-) external beam radiotherapy (EBRT) (before or after HIFU) and can be repeated multiple times. HIFU treatment is performed under real-time monitoring with ultrasound or guided by MRI. Two indications are validated today: Primary care treatment and EBRT failure. The results of HIFU for primary care treatment are similar to standard conformal EBRT, even though no randomized comparative studies have been performed and no 10-year follow up data is yet available for HIFU. Salvage HIFU after EBRT failure is increasing with oncological outcomes, similar to those achieved with surgery but with the advantage of fewer adverse effects. HIFU is an evolving technology perfectly adapted for focal treatment. Thus, HIFU focal therapy is another pathway that must be explored when considering the accuracy and reliability for PCa mapping techniques. HIFU would be particularly suited for such a therapy since it is clear that HIFU outcomes and toxicity are relative to the volume of prostate treated.
影响因子：
19.7
作者：
Turkbey, Baris;Pinto, Peter A.;Choyke, Peter L.
通讯作者：
Choyke, Peter L.
DOI：
10.1093/jnci/djn255
发表时间：
2008-08-20
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
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作者：
Bill-Axelson, Anna;Holmberg, Lars;Johansson, Jan-Erik
通讯作者：
Johansson, Jan-Erik
影响因子：
6.6
作者：
Zelefsky, MJ;Fuks, Z;Leibel, SA
通讯作者：
Leibel, SA