Temperature dependence of the optoacoustic transformation efficiency in ex vivo tissues for application in monitoring thermal therapies
Temperature dependence of the optoacoustic transformation efficiency in ex vivo tissues for application in monitoring thermal therapies
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DOI：
10.1117/1.jbo.17.6.061214
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发表时间：
2012-06-01
影响因子：
3.5
通讯作者：
Pelivanov, Ivan M.
中科院分区：
文献类型：
--
作者：
Nikitin, Sergey M.;Khokhlova, Tatiana D.;Pelivanov, Ivan M.
针对热疗过程中光声（OA）温度监测的应用，得到了OA转换效率与组织温度的校准依赖关系。在25 ℃至80 ℃的温度范围内，在不同的离体组织中进行OA信号幅度与温度的精确测量。选择研究的组织代表不同的结构组分：鸡胸肉（骨骼肌）、猪油（脂肪组织）和猪肝（灌注丰富的组织）。在实验中使用OA信号检测的后向模式和窄探测激光束，以避免组织凝固引起的光散射变化对OA信号幅度的影响。测量进行加热和冷却制度。OA信号幅度温度依赖性在不同温度范围内的特征行为被描述在组织样本的不同结构成分的变化方面。从所获得的校准依赖性的研究组织类型的温度重建的准确性进行评估。(C)2012年，美国光电仪器工程师学会（SPIE）。[DOI：10.1117/1.JBO.17.6.061214]
The calibration dependencies of the optoacoustic (OA) transformation efficiency on tissue temperature are obtained for the application in OA temperature monitoring during thermal therapies. Accurate measurement of the OA signal amplitude versus temperature is performed in different ex vivo tissues in the temperature range 25 degrees C to 80 degrees C. The investigated tissues were selected to represent different structural components: chicken breast (skeletal muscle), porcine lard (fatty tissue), and porcine liver (richly perfused tissue). Backward mode of the OA signal detection and a narrow probe laser beam were used in the experiments to avoid the influence of changes in light scattering with tissue coagulation on the OA signal amplitude. Measurements were performed in heating and cooling regimes. Characteristic behavior of the OA signal amplitude temperature dependences in different temperature ranges were described in terms of changes in different structural components of the tissue samples. The accuracy of temperature reconstruction from the obtained calibration dependencies for the investigated tissue types is evaluated. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.6.061214]