An Evaluation of Factors Associated With Pathogenic PRSS1, SPINK1, CTFR, and/or CTRC Genetic Variants in Patients With Idiopathic Pancreatitis
An Evaluation of Factors Associated With Pathogenic PRSS1, SPINK1, CTFR, and/or CTRC Genetic Variants in Patients With Idiopathic Pancreatitis
复制标题
DOI：
10.1038/ajg.2017.106
复制
发表时间：
2017-08-01
影响因子：
9.8
通讯作者：
Singh, Vikesh K.
中科院分区：
文献类型：
--
作者：
Jalaly, Niloofar Y.;Moran, Robert A.;Singh, Vikesh K.
目的：我们评估了与特发性胰腺炎患者致病性遗传变异相关的因素。方法：在2010年至2015年期间，对所有符合条件的特发性胰腺炎患者进行基因检测（PRSS 1，CFTR，SPINK 1和CTRC）。根据病历回顾将患者分为以下组：（1）急性复发性特发性胰腺炎（ARIP）伴或不伴基础慢性胰腺炎;（2）无阿普病史的特发性慢性胰腺炎（ICP）;（3）原因不明的急性胰腺炎（AP）首次发作
OBJECTIVES: We evaluated factors associated with pathogenic genetic variants in patients with idiopathic pancreatitis.METHODS : Genetic testing (PRSS1, CFTR, SPINK1, and CTRC) was performed in all eligible patients with idiopathic pancreatitis between 2010 to 2015. Patients were classified into the following groups based on a review of medical records: (1) acute recurrent idiopathic pancreatitis (ARIP) with or without underlying chronic pancreatitis; (2) idiopathic chronic pancreatitis (ICP) without a history of ARP; (3) an unexplained first episode of acute pancreatitis (AP)