Clinical application of in situ tissue engineering using a scaffolding technique for reconstruction of the larynx and trachea
Clinical application of in situ tissue engineering using a scaffolding technique for reconstruction of the larynx and trachea
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DOI：
10.1177/000348940811700908
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发表时间：
2008-09-01
影响因子：
1.4
通讯作者：
Asato, Ryo
中科院分区：
文献类型：
--
作者：
Omori, Koichi;Tada, Yasuhiro;Asato, Ryo
目的：本研究的目的是证明原位组织工程的临床应用中使用的支架技术喉和气管tissue.Methods：我们已经开发了一种组织支架由胶原海绵覆盖的Marlex网状管制成的疗效。结果：1例声门下喉狭窄患者，切除甲状软骨、环状软骨及颈段气管，并切除瘢痕及肉芽组织，应用支架植入原位组织工程修复喉气管缺损4例。3例甲状腺癌患者切除肿瘤侵犯的气管和软骨，将支架植入缺损处。术后内窥镜检查在8至34个月的观察期内表现出良好的上皮化的气道腔没有任何obligation.Conclusions：我们目前的原位组织工程技术使用的支架显示出巨大的潜力，用于再生的气道缺损。
Objectives: The objective of the present study was to demonstrate the efficacy of the clinical application of in situ tissue engineering using a scaffolding technique for laryngeal and tracheal tissue.Methods: We have developed a tissue scaffold made from a Marlex mesh tube covered by collagen sponge. Based on successful animal experimental studies, in situ tissue engineering with a scaffold implant was applied to repair the larynx and trachea in 4 patients.Results: In 1 patient with subglottic stenosis, the thyroid cartilage, cricoid cartilage, and cervical trachea with scarring and a granulation were resected and reconstructed by use of the scaffold. In 3 patients with thyroid cancer, the trachea and cri coid cartilage with tumor invasion were resected and the scaffold was implanted into the defect. Postoperative endoscopy during the observation period of 8 to 34 months showed a well-epithelialized airway lumen without any obstruction.Conclusions: Our current technique of in situ tissue engineering using a scaffold shows great potential for use in the regeneration of airway defects.