[4+2] Cyclization of para-Quinone Methide Derivatives with Alkynes
[4+2] Cyclization of para-Quinone Methide Derivatives with Alkynes
复制标题
[4 2] 对醌甲基化物衍生物与炔烃的环化
DOI：
10.1021/acs.joc.7b02942
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发表时间：
2018-02-02
影响因子：
3.6
通讯作者：
Shi, Feng
中科院分区：
文献类型：
--
作者：
Mei, Guang-Jian;Xu, Shao-Li;Shi, Feng
利用邻羟基苯基取代的对醌类衍生物与炔酮或苯的[4 + 2]反应，首次建立了对醌类衍生物与炔的环化反应，高效地构建了铬和杂蒽的支架，产率高达88%。该方案不仅完成了对醌类衍生物的环化反应，而且为构建铬烯和杂蒽类支架提供了一种有效的方法。
The first cyclization of para-quinone methide derivatives with alkynes was established by utilizing the [4 + 2] reaction of ortho-hydroxyphenyl-substituted para-quinone methides with ynones or benzyne, which efficiently constructed the scaffolds of chromene and xanthene in high yields (up to 88%). This protocol has not only fulfilled the task of developing cyclization reactions of para-quinone methide derivatives but also provided an efficient method for constructing chromene and xanthene scaffolds.