Role of FDG-PET and PET/CT in the diagnosis of prolonged febrile states
Role of FDG-PET and PET/CT in the diagnosis of prolonged febrile states
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DOI：
10.1007/s00259-006-0064-z
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发表时间：
2006-08-01
影响因子：
9.1
通讯作者：
Belohlavek, O.
中科院分区：
文献类型：
--
作者：
Jaruskova, M.;Belohlavek, O.
目的：FDG-PET和PET/CT在以持续发热为主要症状的患者中的作用尚未明确。我们在一项回顾性研究中讨论了这一主题。方法：选取2001年5月至2004年12月期间124例可疑关节或血管假体感染引起不明原因发热或持续发热的患者。患者分别行FDG-PET或FDG-PET/CT扫描。67例患者局灶FDG-PET阴性；在本组中，该方法被认为对确定诊断没有帮助，因此没有进行进一步的调查。我们试图为所有PET阳性的患者获得临床证实。结果：57例（46%）患者FDG-PET阳性。其中6例没有进一步的临床资料。随后对51例PET阳性患者和总共118例患者进行了评估。系统性结缔组织疾病17例，淋巴瘤3例，炎症性肠病2例，血管假体感染7例，髋关节或膝关节置换术感染7例，真菌性动脉瘤2例，脓肿4例，艾滋病1例。在8例（16%）患者中发现假阳性。结论：FDG-PET或PET/CT有助于51例PET阳性患者中的84%和118例持续发热患者中的36%确定最终诊断。
Purpose: The role of FDG-PET and PET/CT in patients whose main symptom is prolonged fever has not yet been defined. We addressed this topic in a retrospective study.Methods: A total of 124 patients (referred between May 2001 and December 2004) with fever of unknown origin or prolonged fever due to a suspected infection of a joint or vascular prosthesis were included in the study. The patients underwent either FDG-PET or FDG-PET/CT scanning. Sixty-seven patients had a negative focal FDG-PET finding; in this group the method was regarded as unhelpful in determining a diagnosis, and no further investigation was pursued. We tried to obtain clinical confirmation for all patients with positive PET findings.Results: Fifty-seven (46%) patients had positive FDG-PET findings. In six of them no further clinical information was available. Fifty-one patients with positive PET findings and 118 patients in total were subsequently evaluated. Systemic connective tissue disease was confirmed in 17 patients, lymphoma in three patients, inflammatory bowel disease in two patients, vascular prosthesis infection in seven patients, infection of a hip or knee replacement in seven patients, mycotic aneurysm in two patients, abscess in four patients and AIDS in one patient. In eight (16%) patients the finding was falsely positive.Conclusion: FDG-PET or PET/CT contributed to establishing a final diagnosis in 84% of the 51 patients with positive PET findings and in 36% of all 118 evaluated patients with prolonged fever.