The longitudinal association of the diurnal cortisol rhythm with internalizing and externalizing problems in pre-schoolers. The Generation R Study
The longitudinal association of the diurnal cortisol rhythm with internalizing and externalizing problems in pre-schoolers. The Generation R Study
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DOI：
10.1016/j.psyneuen.2014.08.008
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发表时间：
2014-12-01
影响因子：
3.7
通讯作者：
Tiemeier, Henning
中科院分区：
文献类型：
--
作者：
Saridjan, Nathalie S.;Velders, Fleur P.;Tiemeier, Henning
背景资料：关于皮质醇昼夜节律与幼儿行为问题之间关系的研究得出了不一致的结果。我们测试的假设，在学龄前儿童的昼夜皮质醇节律的变化已经与问题行为的早期生活中的横截面和纵向design.Methods：这项研究被嵌入在一代R，从胎儿的生活开始，以人口为基础的队列。父母在1天内的5个时刻收集婴儿的唾液样本。在322名12-20个月的婴儿中，我们通过计算曲线下面积（AUC）、皮质醇觉醒反应（CAR）和昼夜斜率来确定昼夜皮质醇节律。问题行为进行了评估，在1.5岁和3年的儿童行为检查表/1.5-5 years.Results：皮质醇综合措施和问题行为之间没有横截面的关联，发现在1.5年。然而，皮质醇预测变化的内在问题，从1.5到3年的评估，但不改变外化的问题。基线时AUC水平较高、斜率较平坦、CAR较阳性的儿童在内化问题量表上的得分更高（β/nmol/L AUC：0.08，95% CI：0.00; 0.17，p=0.04; β/nmol/L/h斜率：0.57，95% CI：0.17; 0.98，p=0.006; β/nmol/L CAR：0.04，95% CI：0.01;结论：皮质醇昼夜节律的变化与学龄前儿童内化问题的变化有关。结果表明，在生命早期昼夜皮质醇模式的变化之前的内化问题。(C)2014爱思唯尔有限公司版权所有。
Background: Studies investigating the association between diurnal cortisol rhythm and behavioural problems in young children have yielded inconsistent results. We tested the hypothesis that variations in diurnal cortisol rhythm in pre-schoolers are already related to problem behaviour early in life with a cross-sectional and longitudinal design.Methods: This study was embedded in Generation R, a population-based cohort from foetal life onwards. Parents collected saliva samples from their infant at 5 moments during 1 day. In 322 infants aged 12-20 months, we determined the diurnal cortisol rhythm by calculating the area under the curve (AUC), the cortisol awakening response (CAR), and the diurnal slope. Problem behaviour was assessed at ages 1.5 and 3 years with the Child Behavior Checklist/1.5-5 years.Results: No cross-sectional associations between the cortisol composite measures and problem behaviour were found at 1.5 years. However, cortisol predicted change in internalizing problems as assessed from 1.5 to 3 years, but not change in externalizing problems. Children with higher AUC levels, flatter slopes and a more positive CAR at baseline were more likely to score higher on the Internalizing Problems scale (beta per nmol/L AUC: 0.08, 95% CI: 0.00; 0.17, p=0.04; beta per nmol/L/h slope: 0.57, 95% CI: 0.17; 0.98, p=0.006; beta per nmol/L CAR: 0.04, 95% CI: 0.01; 0.08, p = 0.02) at follow-up.Conclusions: Variations in diurnal cortisol rhythm are associated with change in internalizing problems in pre-schoolers. The results suggest that variations in diurnal cortisol patterns early in life precede internalizing problems. (C) 2014 Elsevier Ltd. All rights reserved.