Characteristics of brain metastases from esophageal carcinoma.
Characteristics of brain metastases from esophageal carcinoma.
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DOI：
10.4103/2152-7806.141468
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发表时间：
2014
影响因子：
--
通讯作者：
Kuratsu J
中科院分区：
文献类型：
--
作者：
Yamamoto T;Kuroda J;Takezaki T;Shinojima N;Hide T;Makino K;Nakamura H;Yano S;Nishi T;Kuratsu J
食管癌（EC）是一种预后不良的主要恶性肿瘤。尽管食道癌很少转移到大脑，但被诊断出患有EC脑转移（BM）的患者数量正在稳步增加。因此，应了解EC引起BM的危险因素。在这里，我们回顾了我们的经验和以前的文献关于BM从EC。在2000年至2013年期间，我们回顾性分析了19例诊断为EC BM并接受治疗的患者的临床特征和神经系统表现，以确定临床风险因素和特征。在所有患者中，病变部分或完全位于胸段食管，诊断时EC病变的平均大小为5.8 ± 2.9 cm，小于先前报道的伴有BM的EC病变的大小。无肺转移者较有肺转移者多见。13例患者中9例（69.2%）为鳞状细胞癌（SqCC），3例（23.0%）为小细胞癌（SmCC）。6名患者未接受检查。尽管腺癌和SqCC患者中BM发生率无升高趋势，但在SmCC患者中观察到了这一趋势。除一例SmCC患者外，所有患者在EC诊断时均超过III期疾病。我们的研究表明，BM可以发生在EC病变小于先前报道的患者中;此外，SmCC可能是EC BM的风险因素。
Esophageal carcinoma (EC) is a major malignancy with a poor prognosis. Although esophageal cancers rarely metastasize to the brain, the number of patients diagnosed with brain metastases (BM) from EC is steadily increasing. Therefore, the risk factors for BM from EC should be known. Here we reviewed our experiences and the previous literature regarding BM from EC. Between 2000 and 2013, we retrospectively reviewed the clinical features and neurological findings of 19 patients diagnosed with and treated for BM from EC to determine the clinical risk factors and features. In all patients, the lesions were partially or completed located in the thoracic esophagus, and the average size of the EC lesion at diagnosis was 5.8 ± 2.9 cm, which was smaller than the previously reported size of EC lesions accompanied by BM. Patients without lung metastases were more common than those with lung metastases. The lesions in the 13 patients included squamous cell carcinoma (SqCC) in 9 (69.2%) and small cell carcinoma (SmCC) in 3 (23.0%). Six patients were not examined. Although there was no trend toward a higher incidence of BM in patients with adenocarcinoma and SqCC, this trend was observed in patients with SmCC. Excluding a single patient with SmCC, all patients had beyond stage III disease at EC diagnosis. Our study suggests that BM can occur in patients with EC lesions smaller than those previously reported; moreover, SmCC may be a risk factor for BM from EC.