The osteoblast-heparan sulfate axis: Control of the bone cell lineage
The osteoblast-heparan sulfate axis: Control of the bone cell lineage
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DOI：
10.1016/j.biocel.2005.03.006
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发表时间：
2005-09-01
影响因子：
4
通讯作者：
Nurcombe, V
中科院分区：
文献类型：
--
作者：
Cool, SM;Nurcombe, V
在成骨过程中，间充质干细胞被招募到成骨细胞谱系中，并逐渐分化为产生矿化细胞外基质的成骨细胞。尽管该基质的大部分有机成分由胶原蛋白组成，但越来越多的证据表明，发育中的基质中最具生物活性的成分是其硫酸乙酰肝素糖胺聚糖补体。这种线性、无支链的糖含有蛋白质结合结构域，可调节数量惊人的有丝分裂影响的流动，从而协调间充质干细胞的定型和生长，并最终协调成骨细胞表型。已知对该过程很重要的硫酸乙酰肝素结合因子包括声波刺猬、成纤维细胞生长因子及其受体、转化生长因子超家族的成员，以及胶原蛋白、层粘连蛋白和纤连蛋白。这些糖在发育过程中如何变化，以将促有丝分裂/分化影响的正确组合结合在一起，从而触发成骨的连续阶段，这是目前深入研究的焦点。 (C) 2005 Elsevier Ltd. 保留所有权利。
During osteogenesis, mesenchymal stem cells are recruited to the osteoblast lineage and progressively differentiate into osteoblasts that produce a mineralised extracellular matrix. Although most of the organic component of this matrix is comprised of collagen, growing evidence suggests the most bioactive element of a developing matrix is its heparan sulfate glycosaminoglycan complement. This species of linear, unbranched sugars contain protein-binding domains that regulate the flow of an astonishing number of mitogenic influences that coordinate mesenchymal stem cell commitment and growth, and ultimately, osteoblast phenotype. Among the heparan sulfate-binding factors known to be important to this process are sonic hedgehog, the fibroblast growth factors and their receptors, members of the transforming growth factor superfamily, as well as the collagens, laminins and fibronectins. How these sugars change during development to bring together the right combination of mitogenic/differentiative influences to trigger the successive phases of osteogenesis is currently the focus of intense research. (C) 2005 Elsevier Ltd. All rights reserved.