SCH-37137, A NOVEL ANTIFUNGAL COMPOUND PRODUCED BY A MICROMONOSPORA SP - TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE AND BIOLOGICAL PROPERTIES
SCH-37137, A NOVEL ANTIFUNGAL COMPOUND PRODUCED BY A MICROMONOSPORA SP - TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE AND BIOLOGICAL PROPERTIES
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DOI：
10.7164/antibiotics.41.13
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发表时间：
1988-01-01
影响因子：
3.3
通讯作者：
TRUUMEES, I
中科院分区：
文献类型：
--
作者：
COOPER, R;HORAN, AC;TRUUMEES, I
从一株小单孢菌（Micromonosporasp.）的发酵液中分离得到一个新的抗真菌化合物Sch 37137，SCC 1792。Sch 37137在结构上与A 19009有关，A 19009是一种以前从链霉菌属中发现的二肽。128 μ g/ml）在沙氏葡萄糖、酵母-氮和改良的Eagles最低必需培养基中的活性; 12 μ g/ml）和皮肤真菌（平均MIC ≥ 12 μ g/ml）。0.8μ g/ml）在MA培养基中显著提高。
A new antifungal compound, Sch 37137, was isolated from the cultured broth of a Micromonospora sp., SCC 1792. Sch 37137 is structurally related to A 19009, a dipeptide previously discovered from a Streptomyces sp. The compound was weakly active against species of Candida and dermatophytes (mean MICs .gtoreq. 128 .mu.g/ml) in Sabouraud dextrose, yeast-nitrogen and modified Eagles minimum essential media; however activity against Candida sp. (mean MICs .gtoreq. 12 .mu.g/ml) and dermatophytes (mean MICs .gtoreq. 0.8 .mu.g/ml) significantly improved in MA medium.