Increasing burden of noninfectious lung disease in persons living with HIV: a 7-year study using the French nationwide hospital administrative database
Increasing burden of noninfectious lung disease in persons living with HIV: a 7-year study using the French nationwide hospital administrative database
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DOI：
10.1183/13993003.00359-2018
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发表时间：
2018-09-01
影响因子：
24.3
通讯作者：
Quantin, Catherine
中科院分区：
文献类型：
--
作者：
Maitre, Thomas;Cottenet, Jonathan;Quantin, Catherine
艾滋病毒感染者的艾滋病发病率总体下降，肺部疾病谱发生变化。我们的目的是提供一个流行病学更新有关肺部疾病的患病率在PLHIV住院在法国。我们分析了肺部疾病的患病率在PLHIV住院在法国从2007年至2013年，从法国全国医院医疗信息数据库，并在4年的随访中评估了艾滋病毒与非传染性疾病之间的关系-2007年至2013年期间，法国共有52091名艾滋病毒感染者住院治疗。在因肺部疾病住院的艾滋病毒感染者中，2007年至2013年期间，非感染性肺部疾病从45.6%显著增加到54.7%，而患有至少一种感染性肺部疾病的患者比例显著下降。2010年，有10，067名住院感染艾滋病毒的患者与8，244，682名住院非感染艾滋病毒的患者进行了比较。在30-49岁的患者中，HIV感染与慢性阻塞性肺疾病（COPD）、慢性呼吸衰竭、肺气肿、肺纤维化和肺动脉高压（PAH）相关，即使在调整吸烟因素后也是如此。
An overall reduction in the incidence of AIDS and a change in the spectrum of lung disease have been noticed in persons living with HIV (PLHIV). Our aim was to provide an epidemiological update regarding the prevalence of lung diseases in PLHIV hospitalised in France.We analysed the prevalence of lung disease in PLHIV hospitalised in France from 2007 to 2013, from the French nationwide hospital medical information database, and assessed the association between HIV and incident noninfectious disease over 4 years of follow-up.A total of 52 091 PLHIV were hospitalised in France between 2007 and 2013. Among PLHIV hospitalised with lung disease, noninfectious lung diseases increased significantly from 45.6% to 54.7% between 2007 and 2013, whereas the proportion of patients with at least one infectious lung disease decreased significantly. In 2010, 10 067 prevalent hospitalised PLHIV were compared with 8 244 682 hospitalised non-PLHIV. In 30-49-year-old patients, HIV infection was associated with chronic obstructive pulmonary disease (COPD), chronic respiratory failure, emphysema, lung fibrosis and pulmonary arterial hypertension (PAH) even after adjustment for smoking.The emergence of noninfectious lung disease, in particular COPD, emphysema, lung fibrosis, PAH and chronic respiratory disease, in PLHIV would justify mass screening in this population.