Time-Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover Trial
Time-Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover Trial
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DOI：
10.1002/oby.22449
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发表时间：
2019-05-01
期刊：
影响因子：
6.9
通讯作者：
Heilbronn, Leonie K.
中科院分区：
文献类型：
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作者：
Hutchison, Amy T.;Regmi, Prashant;Heilbronn, Leonie K.
目的本研究旨在评估9小时限时喂养（TRF）、早期（TRFe）或延迟（TRFd）对有2型糖尿病风险的男性糖耐量的影响。方法15名男性（年龄55 ± 3岁，BMI 33.9 ± 0.8 kg/m2）在基线评估7天和两个7天TRF条件期间佩戴连续葡萄糖监测仪。参与者被随机分配至TRFe（上午8点至下午5点）或TRFd（下午12点至晚上9点），间隔2周的洗脱期。在第0天和第7天上午8点（TRFe）或下午12点（TRFd）标准餐后计算葡萄糖、胰岛素、甘油三酯、非酯化脂肪酸和胃肠激素增量曲线下面积。结果TRF改善了葡萄糖耐量，通过第7天与第0天葡萄糖增量曲线下面积（P = 0.001）和空腹甘油三酯（P = 0.003）的减少进行评估。然而，有没有用餐时间的TRF相互作用的任何变量检查。TRF对空腹和餐后胰岛素、非酯化脂肪酸或胃肠激素也没有影响。与基线相比，TRFe组（P = 0.02）通过动态血糖监测仪测得的平均空腹血糖较低，但TRFd组（P = 0.17）无此差异，但TRF条件之间无差异。结论：虽然只有TRFe降低了平均空腹血糖，但TRF改善了2型糖尿病风险男性对试验餐的血糖反应，无论TRF开始的时间如何。
Objective This study aimed to assess the effects of 9-hour time-restricted feeding (TRF), early (TRFe) or delayed (TRFd), on glucose tolerance in men at risk for type 2 diabetes. Methods Fifteen men (age 55 +/- 3 years, BMI 33.9 +/- 0.8 kg/m(2)) wore a continuous glucose monitor for 7 days of baseline assessment and during two 7-day TRF conditions. Participants were randomized to TRFe (8 am to 5 pm) or TRFd (12 pm to 9 pm), separated by a 2-week washout phase. Glucose, insulin, triglycerides, nonesterified fatty acids, and gastrointestinal hormone incremental areas under the curve were calculated following a standard meal on days 0 and 7 at 8 am (TRFe) or 12 pm (TRFd). Results TRF improved glucose tolerance as assessed by a reduction in glucose incremental area under the curve (P = 0.001) and fasting triglycerides (P = 0.003) on day 7 versus day 0. However, there were no mealtime by TRF interactions in any of the variables examined. There was also no effect of TRF on fasting and postprandial insulin, nonesterified fatty acids, or gastrointestinal hormones. Mean fasting glucose by continuous glucose monitor was lower in TRFe (P = 0.02) but not TRFd (P = 0.17) versus baseline, but there was no difference between TRF conditions. Conclusions While only TRFe lowered mean fasting glucose, TRF improved glycemic responses to a test meal in men at risk for type 2 diabetes regardless of the clock time that TRF was initiated.