Family history as a risk factor for colorectal cancer in inflammatory bowel disease
Family history as a risk factor for colorectal cancer in inflammatory bowel disease
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DOI：
10.1053/gast.2001.24052
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发表时间：
2001-05-01
期刊：
影响因子：
29.4
通讯作者：
Ekbom, A
中科院分区：
文献类型：
--
作者：
Askling, J;Dickman, PW;Ekbom, A
背景与目的：家族性结直肠癌（CRC）是健康人结直肠癌的危险因素，病例对照研究表明，可能在溃疡性结肠炎中也是如此。我们对家族性炎症性肠病（IBD）的癌症风险知之甚少，我们评估了家族性CRC （IBD）对IBD患者发生CRC风险的重要性，方法：基于人群的队列研究，对1941年至1995年出生的19876例溃疡性结肠炎或克罗恩病患者进行了基于登记的随访和评估，对家族性CRC和IBD进行了评估，CRC风险评估为发病率比例（“绝对风险”IP）和相对风险（RR），结果：家族性CRC与2倍以上的CRC风险相关（校正RR = 2.5, 95%可信区间1.4-4.4），54岁时CRC的IP从3.8%增加到6.9%，50岁前一级亲属诊断为CRC的患者RR较高（9.2,95%可信区间3.7-23），IP最高（29%），与家族性IBD无关联。结论：关于结直肠癌家族史的信息可能是识别IBD患者发生结直肠癌风险升高的一种简单方法。
Background & Aims: Familial colorectal cancer (CRC) is a risk factor for CRC in healthy individuals and, as indicated by case-control studies, possibly in ulcerative colitis. Little is known about the cancer risk in familial inflammatory bowel disease (IBD), We assessed the significance of familial CRC, or IBD, on the risk for CRC in patients with IBD, Methods: Population-based cohort study of 19,876 individuals with ulcerative colitis or Crohn's disease born between 1941 and 1995, Registry-based follow-up and assessment of familial CRC, and IBD, Risk of CRC assessed as incidence proportion ("absolute risk," IP) and relative risk (RR), Results: Familial CRC was associated with a more than 2-fold risk of CRC (adjusted RR = 2.5, 95% confidence interval 1.4-4.4) and an increase in the IP of CRC at 54 years of age from 3.8% to 6.9%, Patients with a first-degree relative diagnosed with CRC before 50 years of age had a higher RR (9.2, 95% confidence interval 3.7-23) and the highest IP (29%), No association with familial IBD was observed. Conclusions: Information on family history of CRC may be a simple way to identify individuals with IBD at elevated risk of developing CRC.