A review on effects of conjugated linoleic fatty acid (CLA) upon body composition and energetic metabolism.
A review on effects of conjugated linoleic fatty acid (CLA) upon body composition and energetic metabolism.
复制标题
DOI：
10.1186/s12970-015-0097-4
复制
发表时间：
2015
影响因子：
5.1
通讯作者：
Lehnen AM
中科院分区：
文献类型：
--
作者：
Lehnen TE;da Silva MR;Camacho A;Marcadenti A;Lehnen AM
共轭亚油酸（CLA）在反刍动物脂肪中含量很高，它似乎有利于改善身体组成和心脏代谢危险因素。CLA降低体脂水平的能力以及其对血糖谱、动脉粥样硬化和癌症的有益作用已经在实验模型中得到证实。此外，补充CLA还可以调节免疫功能，促进糖原的再合成，促进骨矿化。CLA还能促进脂肪分解，减少脂肪酸在脂肪组织上的积累，其作用机制可能是降低脂蛋白酶活性，提高CAT-1活性，与PPARγ相互作用，提高UCP-1表达。虽然在人体中进行的研究表明，补充CLA对减肥有一定的好处，但结果仍然不一致。此外，有些药物已显示出副作用，如对葡萄糖代谢和脂质分布的负面影响。本文的目的是回顾有关CLA对能量代谢和身体组成的益处的现有数据，强调作用机制。
Conjugated linoleic acid (CLA) is highly found in fats from ruminants and it appears to favorably modify the body composition and cardiometabolic risk factors. The capacity of CLA to reduce the body fat levels as well as its benefic actions on glycemic profile, atherosclerosis and cancer has already been proved in experimental models. Furthermore, CLA supplementation may modulate the immune function, help re-synthetize of glycogen and potentiate the bone mineralization. CLA supplementation also could increase the lipolysis and reduce the accumulation of fatty acids on the adipose tissue; the putative mechanisms involved may be its action in reducing the lipase lipoprotein activity and to increase the carnitine-palmitoil-transferase-1 (CAT-1) activity, its interaction with PPARγ, and to raise the expression of UCP-1. Although studies made in human have shown some benefits of CLA supplementation as the weight loss, the results are still discordant. Moreover, some have shown adverse effects, such as negative effects on glucose metabolism and lipid profile. The purpose of this article is to review the available data regarding the benefits of CLA on the energetic metabolism and body composition, emphasizing action mechanisms.