Strain stiffening in collagen I networks
Strain stiffening in collagen I networks
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DOI：
10.1002/bip.22133
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发表时间：
2013-01-01
期刊：
影响因子：
2.9
通讯作者：
Kaufman, Laura J.
中科院分区：
文献类型：
--
作者：
Motte, Stephanie;Kaufman, Laura J.
生物聚合物凝胶表现出通常在合成凝胶中看不到的应变硬化。在这里，我们研究了胶原蛋白I凝胶的应变硬化行为，该凝胶显示了来自多种来源的弹性，包括通过端肽交联，通过低温凝胶捆绑，以及外源与genipin交联。在所有情况下，发现这些凝胶表现出应变硬化；一般来说，在浓度较高的凝胶和纤维束较粗的凝胶中，应变硬化发生得较早，屈服应变较低，应变硬化程度较小。在暴露于高应变后，所有凝胶的恢复都是实质性的，并且相似，这表明大部分的硬化来自可逆的网络变形。本研究的一个关键发现是具有相同储存模量和损失模量的I型胶原凝胶可能表现出不同的非线性响应和不同的高应变恢复能力。(c) 2012 Wiley期刊有限公司
Biopolymer gels exhibit strain stiffening that is generally not seen in synthetic gels. Here, we investigate the strain-stiffening behavior in collagen I gels that demonstrate elasticity derived from a variety of sources including crosslinking through telopeptides, bundling through low-temperature gelation, and exogenous crosslinking with genipin. In all cases, it is found that these gels exhibit strain stiffening; in general, onset of strain stiffening occurs earlier, yield strain is lower, and degree of strain stiffening is smaller in higher concentration gels and in those displaying thick fibril bundles. Recovery after exposure to high strains is substantial and similar in all gels, suggesting that much of the stiffening comes from reversible network deformations. A key finding of this study is that collagen I gels of identical storage and loss moduli may display different nonlinear responses and different capacities to recover from high strain. (c) 2012 Wiley Periodicals, Inc.