Near-infrared rechargeable "optical battery" implant for irradiation-free photodynamic therapy
Near-infrared rechargeable "optical battery" implant for irradiation-free photodynamic therapy
复制标题
用于无辐射光动力治疗的近红外可充电“光电池”植入物
DOI：
10.1016/j.biomaterials.2018.02.029
复制
发表时间：
2018-05-01
期刊：
影响因子：
14
通讯作者：
Zhang, Fan
中科院分区：
文献类型：
--
作者：
Hu, Lidan;Wang, Peiyuan;Zhang, Fan
光动力治疗作为一种微创或无创的肿瘤治疗方法，受到了广泛的关注。然而，由于长时间照射造成的低组织穿透性和光热效应，阻碍了它们的进一步应用。本文通过在生物相容性聚二甲基硅氧烷中嵌入上转换材料、持续发光材料和光敏剂，制备了一种用于无辐照PDT的近红外（NIR）可充电“光学电池”。经980 nm近红外激光快速充电5 s后，PDT“光电池”可以产生绿色持续发光，并产生细胞毒性单线态氧，连续无照射PDT（类似于30分钟），无需外部照射。由于近红外光充电源对深层组织的穿透和间断短曝光，“光学电池”仍然可以充电，在深层组织（约4mm）中连续产生单线态氧气，光热效应低。PDT植入物可以很容易地针对不同的病灶部位进行尺寸和形状的优化，并通过添加其他功能成分（例如CaO2用于吸氧以克服缺氧肿瘤）来实现不同的功能。这种近红外可充电“光电池”有效抑制肿瘤增殖的能力，可能为未来的临床应用带来下一代智能刺激响应纳米医学和无创光生物刺激研究。(C) 2018 Elsevier Ltd.版权所有。
As a minimal or noninvasive therapeutic method for tumors, photodynamic therapy (PDT) induced by the external laser irradiations has attracted great attentions. However, the UV-visible responsive property with low tissue penetration and photothermal effect from the prolonged irradiation impedes their further applications. Herein, a near-infrared (NIR) rechargeable "optical battery" for irradiation-free PDT is fabricated by embedding upconversion materials, persistent luminescence materials, photosensitizer into biocompatible polydimethylsiloxane. After 5 s quickly charged by 980-nm NIR laser, the PDT "optical battery" can generate green persistent luminescence and produce cytotoxic singlet oxygen for continuous irradiation-free PDT (similar to 30 min) without external irradiation. Due to deep tissue penetration and discontinuous short exposure of NIR light charging source, the "optical battery" can still be charged to continuously generate singlet oxygen in deep tissue (similar to 4 mm) with low photothermal effect. The PDT implant can be easily optimized in size and shape aiming at different nidus sites and achieved different functions by adding other functional components (e.g. CaO2 for oxygen envolving to overcome hypoxia tumor). The effective tumor proliferation inhibiting capability of this NIR rechargeable "optical battery" may give rise to next generation of intelligent stimuli-responsive nanomedicine and noninvasive photo bio-stimulation research for future clinical applications. (C) 2018 Elsevier Ltd. All rights reserved.