A population perspective on diagnostic criteria for Parkinson's disease
A population perspective on diagnostic criteria for Parkinson's disease
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DOI：
10.1212/wnl.48.5.1277
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发表时间：
1997-05-01
期刊：
影响因子：
9.9
通讯作者：
Maraganore, DM
中科院分区：
文献类型：
--
作者：
deRijk, MC;Rocca, WA;Maraganore, DM
对于帕金森病（PD），诊断标准的选择对研究结果的影响知之甚少。使用来自三个社区研究（来自阿根廷、荷兰、意大利）的PD数据，我们比较了几种诊断标准对患病率的影响。每一组都是基于基本体征——静息性震颤、运动迟缓、僵硬、姿势反射受损——并要求排除其他帕金森病。一些组有与症状持续时间、体征不对称或对药物反应有关的额外要求。在患病率方面，低得多的估计与不对称体征和药物反应的要求有关。这些临床特征的评估在社区研究中可能不实用。受损的姿势反射，作为一个主要的标志，似乎是多余的。对于帕金森氏症的社区研究，我们推荐以下诊断标准：在没有其他明显的帕金森氏症病因的情况下，至少有静息性震颤、运动迟缓或僵硬中的两种。
For Parkinson's disease (PD), little is known about how the choice of diagnostic criteria affects research results. Using data on PD from three community studies (from Argentina, the Netherlands, Italy), we compared the impact on prevalence of several sets of diagnostic criteria. Each set was based on cardinal signs-resting tremor, bradykinesia, rigidity, impaired postural reflexes-and required that other parkinsonism be excluded. Some sets had additional requirements related to duration of symptoms, asymmetry of signs, or response to medication. In terms of prevalence, much lower estimates were associated with the requirements of asymmetry of signs and response to medication. The assessment of these clinical features may not be practical in community studies. Impaired postural reflexes, as a cardinal sign, seemed superfluous. For community studies of PD, we recommend the following diagnostic criteria: at least two of resting tremor, bradykinesia, or rigidity, in the absence of other apparent causes of parkinsonism.