Multiple Lentigines Syndrome: A Comparison of Normal Skin and Lentiginous Skin by Electron Microscopy and Immunohistochemical Staining
Multiple Lentigines Syndrome: A Comparison of Normal Skin and Lentiginous Skin by Electron Microscopy and Immunohistochemical Staining
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多发性雀斑综合征：通过电子显微镜和免疫组织化学染色比较正常皮肤和雀斑皮肤
DOI：
10.1111/j.1346-8138.1998.tb02422.x
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Hyuk Jae Kwon
中科院分区：
文献类型：
--
作者：
J. Choi;S. Chang;Soo;W. Park;Hyuk Jae Kwon
一名 26 岁的韩国男性表现出全身性雀斑、下巴轻微突出、身材矮小以及符合常染色体显性遗传模式的家族史。 1岁时出现多发性雀斑，4岁时遍布全身，包括头皮、手掌和脚底。躯干上有几个大的深色色素斑，但没有发现其他皮肤异常。我们通过电子显微镜和光学显微镜以及免疫组织化学染色对正常皮肤和雀斑进行了组织学研究。色素皮肤的常规苏木精-伊红染色显示出色素沉着的基底层和棘层以及突出的网状脊。丰塔纳-马森染色显示色素斑的基底层和棘层上有巨大的黑色色素沉着。色素病变的 S-100 蛋白染色显示每单位皮肤面积的黑素细胞数量增加。超微结构研究表明，雀斑样表皮的角质形成细胞内存在大量聚集的黑素体，但正常皮肤或雀斑样痣中均不存在巨大的黑素体。
A 26‐year‐old Korean man exhibited generalized lentigines, a slight prominence of the chin, short stature, and a familial history consistent with the autosomal dominant mode of inheritance. The multiple lentigines appeared at the age of 1 and spread over his entire body including the scalp, palms, and soles by the age of 4. There were several large dark pigmented spots on the trunk, but no other skin abnormalities were found. We performed histologic studies of the normal skin and the lentigo by both electron and light microscopy with immunohistochemical stains. Routine hematoxylin‐eosin staining of the pigmented skin revealed heavily pigmented basal and spinous layers and prominent rete ridges. Fontana‐Masson stain showed enormous black pigmentations on the basal and spinous layers of the pigmented macule. S‐100 protein stain of the pigmented lesion demonstrated an increased number of melanocytes per unit skin area. Ultrastructural studies showed the presence of extensive aggregated melanosomes within the keratinocytes in the epidermis of lentigo, but not the presence of giant melanosomes in either normal skin or lentigines.