A study of DNA damage recognition and repair gene polymorphisms in relation to cancer predisposition and G2 chromosomal radiosensitivity.
A study of DNA damage recognition and repair gene polymorphisms in relation to cancer predisposition and G2 chromosomal radiosensitivity.
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DOI：
10.1002/em.20633
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发表时间：
2011-01
影响因子：
2.8
通讯作者：
Boice, John D., Jr.
中科院分区：
文献类型：
--
作者：
Curwen, Gillian B.;Murphy, Samantha;Tawn, Elizabeth J.;Winther, Jeanette F.;Boice, John D., Jr.
先前报道的APEX Asp148Glu SNP与癌症的关联，以及XRCC3 Thr241Met和hOGG1 Ser326Cys SNP位点与G2染色体放射敏感性的关联，在一项针对30名儿童和青年癌症幸存者、他们的30名伴侣和55名后代的新研究中进行了调查。另外一个SNP hOGG1 Arg46Gln也进行了分析。29个家庭包括53个后代的G2染色体放射敏感性数据可用。没有观察到基因型与癌症或G2染色体放射敏感性的显著关联。
The previously reported association of the APEX Asp148Glu SNP with cancer and the suggestion of associations of the XRCC3 Thr241Met and hOGG1 Ser326Cys SNP sites with G2 chromosomal radiosensitivity were investigated in a new study of 30 childhood and young adult cancer survivors, their 30 partners and 55 offspring. An additional SNP, hOGG1 Arg46Gln, was also analysed. Data on G2 chromosomal radiosensitivity was available on 29 of the families including 53 offspring. No significant associations of genotype with cancer or G2 chromosomal radiosensitivity were observed.
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Scott, D
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