DNA-catalyzed polymerization
DNA-catalyzed polymerization
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DOI：
10.1021/ja017319j
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发表时间：
2002-02-06
影响因子：
15
通讯作者：
Lynn, DG
中科院分区：
文献类型：
--
作者：
Li, ZY;Zhang, ZYJ;Lynn, DG
天然DNA寡聚物被证明是通过还原胺化聚合5 '-氨基-3'-乙酰基-修饰的胸苷/腺苷核苷的立体选择性催化剂。反应遵循逐步增长动力学，以反平行方向读取编码序列和链长信息。模板中的单个错配以>100：1的水平被选择。因此，建立了一种方法，将生物聚合物编码的信息立体选择性地翻译成序列和链长特异性合成聚合物。
Native DNA oligomers are shown to be stereoselective catalysts for the polymerization of 5‘-amino-3‘-acetaldehyde-modified thymidine/adenosine nucleosides through reductive amination. The reaction follows step-growth kinetics to read the encoded sequence and chain-length information in the antiparallel direction. Single mismatches in the template are selected against at a level of >100:1. A method is therefore established to translate biopolymer-encoded information stereoselectively into sequence- and chain-length specific synthetic polymers.